Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS029633-06
Application #
2735608
Study Section
Physiology Study Section (PHY)
Program Officer
Baughman, Robert W
Project Start
1991-07-15
Project End
1998-08-31
Budget Start
1998-07-01
Budget End
1998-08-31
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Zhu, Jing; Gomez, Barbara; Watanabe, Itaru et al. (2005) Amino acids in the pore region of Kv1 potassium channels dictate cell-surface protein levels: a possible trafficking code in the Kv1 subfamily. Biochem J 388:355-62
Sutachan, Jhon J; Watanabe, Itaru; Zhu, Jing et al. (2005) Effects of Kv1.1 channel glycosylation on C-type inactivation and simulated action potentials. Brain Res 1058:30-43
Watanabe, Itaru; Zhu, Jing; Recio-Pinto, Esperanza et al. (2004) Glycosylation affects the protein stability and cell surface expression of Kv1.4 but Not Kv1.1 potassium channels. A pore region determinant dictates the effect of glycosylation on trafficking. J Biol Chem 279:8879-85
Zhu, Jing; Watanabe, Itaru; Gomez, Barbara et al. (2003) Heteromeric Kv1 potassium channel expression: amino acid determinants involved in processing and trafficking to the cell surface. J Biol Chem 278:25558-67
Castillo, Cecilia; Thornhill, William B; Zhu, Jing et al. (2003) The permeation and activation properties of brain sodium channels change during development. Brain Res Dev Brain Res 144:99-106
Zhu, Jing; Watanabe, Itaru; Poholek, Amanda et al. (2003) Allowed N-glycosylation sites on the Kv1.2 potassium channel S1-S2 linker: implications for linker secondary structure and the glycosylation effect on channel function. Biochem J 375:769-75
Zhu, Jing; Watanabe, Itaru; Gomez, Barbara et al. (2003) Trafficking of Kv1.4 potassium channels: interdependence of a pore region determinant and a cytoplasmic C-terminal VXXSL determinant in regulating cell-surface trafficking. Biochem J 375:761-8
Thornhill, W B; Watanabe, I; Sutachan, J J et al. (2003) Molecular cloning and expression of a Kv1.1-like potassium channel from the electric organ of Electrophorus electricus. J Membr Biol 196:1-8
Watanabe, Itaru; Wang, Hong-Gang; Sutachan, Jhon J et al. (2003) Glycosylation affects rat Kv1.1 potassium channel gating by a combined surface potential and cooperative subunit interaction mechanism. J Physiol 550:51-66
Zhu, L; Wu, X; Wu, M B et al. (2001) Cloning and characterization of G protein-gated inward rectifier K+ channel (GIRK1) isoforms from heart and brain. J Mol Neurosci 16:21-32

Showing the most recent 10 out of 20 publications