Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS029875-06
Application #
2267987
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1991-08-01
Project End
1998-07-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Neurosciences
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Medrano, S; Steward, O (2001) Differential mRNA localization in astroglial cells in culture. J Comp Neurol 430:56-71
Schauwecker, P E; Ramirez, J J; Steward, O (2000) Genetic dissection of the signals that induce synaptic reorganization. Exp Neurol 161:139-52
Steward, O; Kelley, M S; Schauwecker, P E (1997) Signals that regulate astroglial gene expression: induction of GFAP mRNA following seizures or injury is blocked by protein synthesis inhibitors. Exp Neurol 148:100-9
Steward, O; Trimmer, P A (1997) Genetic influences on cellular reactions to CNS injury: the reactive response of astrocytes in denervated neuropil regions in mice carrying a mutation (Wld(S)) that causes delayed Wallerian degeneration. J Comp Neurol 380:70-81
Schauwecker, P E; Steward, O (1997) Genetic influences on cellular reactions to brain injury: activation of microglia in denervated neuropil in mice carrying a mutation (Wld(S)) that causes delayed Wallerian degeneration. J Comp Neurol 380:82-94
Fujiki, M; Steward, O (1997) High frequency transcranial magnetic stimulation mimics the effects of ECS in upregulating astroglial gene expression in the murine CNS. Brain Res Mol Brain Res 44:301-8
Schauwecker, P E; Steward, O (1997) Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches. Proc Natl Acad Sci U S A 94:4103-8
Kelley, M S; Steward, O (1996) The role of postlesion seizures and spreading depression in the upregulation of glial fibrillary acidic protein mRNA after entorhinal cortex lesions. Exp Neurol 139:83-94
Kelley, M S; Steward, O (1996) The process of reinnervation in the dentate gyrus of adult rats: physiological events at the time of the lesion and during the early postlesion period. Exp Neurol 139:73-82
Bonthius, D J; Lothman, E W; Steward, O (1995) The role of extracellular ionic changes in upregulating the mRNA for glial fibrillary acidic protein following spreading depression. Brain Res 674:314-28

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