Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS029886-02
Application #
2268002
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1994-12-01
Project End
1998-11-30
Budget Start
1995-12-06
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Oklahoma Norman
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
848348348
City
Norman
State
OK
Country
United States
Zip Code
73019
Dryhurst, G (2001) Are dopamine, norepinephrine, and serotonin precursors of biologically reactive intermediates involved in the pathogenesis of neurodegenerative brain disorders? Adv Exp Med Biol 500:373-96
Shen, X M; Li, H; Dryhurst, G (2000) Oxidative metabolites of 5-S-cysteinyldopamine inhibit the alpha-ketoglutarate dehydrogenase complex: possible relevance to the pathogenesis of Parkinson's disease. J Neural Transm 107:959-78
Han, J; Cheng, F C; Yang, Z et al. (1999) Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease. J Neurochem 73:1683-95
Shen, X M; Dryhurst, G (1998) Iron- and manganese-catalyzed autoxidation of dopamine in the presence of L-cysteine: possible insights into iron- and manganese-mediated dopaminergic neurotoxicity. Chem Res Toxicol 11:824-37
Li, H; Shen, X M; Dryhurst, G (1998) Brain mitochondria catalyze the oxidation of 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1) to intermediates that irreversibly inhibit complex I and scavenge glutathione: potential relevance to the pathogenesis of J Neurochem 71:2049-62
Shen, X M; Zhang, F; Dryhurst, G (1997) Oxidation of dopamine in the presence of cysteine: characterization of new toxic products. Chem Res Toxicol 10:147-55
Wrona, M Z; Yang, Z; Zhang, F et al. (1997) Potential new insights into the molecular mechanisms of methamphetamine-induced neurodegeneration. NIDA Res Monogr 173:146-74
Li, H; Dryhurst, G (1997) Irreversible inhibition of mitochondrial complex I by 7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1): a putative nigral endotoxin of relevance to Parkinson's disease. J Neurochem 69:1530-41
Shen, X M; Xia, B; Wrona, M Z et al. (1996) Synthesis, redox properties, in vivo formation, and neurobehavioral effects of N-acetylcysteinyl conjugates of dopamine: possible metabolites of relevance to Parkinson's disease. Chem Res Toxicol 9:1117-26
Cheng, F C; Kuo, J S; Chia, L G et al. (1996) Elevated 5-S-cysteinyldopamine/homovanillic acid ratio and reduced homovanillic acid in cerebrospinal fluid: possible markers for and potential insights into the pathoetiology of Parkinson's disease. J Neural Transm 103:433-46

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