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Seo, Hyemyung; Kim, Woori; Isacson, Ole (2008) Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients. Hum Mol Genet 17:3144-53
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Seo, Hyemyung; Sonntag, Kai-Christian; Isacson, Ole (2004) Generalized brain and skin proteasome inhibition in Huntington's disease. Ann Neurol 56:319-28
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Isacson, Ole; Bjorklund, Lars M; Schumacher, James M (2003) Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells. Ann Neurol 53 Suppl 3:S135-46; discussion S146-8
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Cicchetti, F; Fodor, W; Deacon, T W et al. (2003) Immune parameters relevant to neural xenograft survival in the primate brain. Xenotransplantation 10:41-9
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Bjorklund, Lars M; Isacson, Ole (2002) Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease. Prog Brain Res 138:411-20
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Cicchetti, F; Costantini, L; Belizaire, R et al. (2002) Combined inhibition of apoptosis and complement improves neural graft survival of embryonic rat and porcine mesencephalon in the rat brain. Exp Neurol 177:376-84
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Haque, N S; Isacson, O (2000) Neurotrophic factors NGF and FGF-2 alter levels of huntingtin (IT15) in striatal neuronal cell cultures. Cell Transplant 9:623-7
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Freeman, T B; Cicchetti, F; Hauser, R A et al. (2000) Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. Proc Natl Acad Sci U S A 97:13877-82
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Isacson, O; Deacon, T (1997) Neural transplantation studies reveal the brain's capacity for continuous reconstruction. Trends Neurosci 20:477-82
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Haque, N S; Borghesani, P; Isacson, O (1997) Therapeutic strategies for Huntington's disease based on a molecular understanding of the disorder. Mol Med Today 3:175-83
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