Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS030152-04
Application #
2268213
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1991-09-30
Project End
1998-02-28
Budget Start
1995-03-15
Budget End
1996-02-29
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Leiden University
Department
Type
DUNS #
City
Leiden
State
Country
Netherlands
Zip Code
2311-Z
Taschner, P E M; Losekoot, M; Breuning, M H et al. (2005) [From gene to disease; from CLN1, CLN2 and CLN3 to neuronal ceroid lipofuscinosis] Ned Tijdschr Geneeskd 149:300-3
Taschner, P E; Franken, P F; van Berkel, L et al. (1999) Genetic heterogeneity of neuronal ceroid lipofuscinosis in The Netherlands. Mol Genet Metab 66:339-43
Mitchison, H M; Bernard, D J; Greene, N D et al. (1999) Targeted disruption of the Cln3 gene provides a mouse model for Batten disease. The Batten Mouse Model Consortium [corrected] Neurobiol Dis 6:321-34
Munroe, P B; Mitchison, H M; O'Rawe, A M et al. (1997) Spectrum of mutations in the Batten disease gene, CLN3. Am J Hum Genet 61:310-6
Mitchison, H M; Taschner, P E; Kremmidiotis, G et al. (1997) Structure of the CLN3 gene and predicted structure, location and function of CLN3 protein. Neuropediatrics 28:12-4
Mitchison, H M; Munroe, P B; O'Rawe, A M et al. (1997) Genomic structure and complete nucleotide sequence of the Batten disease gene, CLN3. Genomics 40:346-50
Taschner, P E; de Vos, N; Breuning, M H (1997) Rapid detection of the major deletion in the Batten disease gene CLN3 by allele specific PCR. J Med Genet 34:955-6
Munroe, P B; O'Rawe, A M; Mitchison, H M et al. (1997) Strategy for mutation detection in CLN3: characterisation of two Finnish mutations. Neuropediatrics 28:15-7
Taschner, P E; de Vos, N; Breuning, M H (1997) Cross-species homology of the CLN3 gene. Neuropediatrics 28:18-20
Taschner, P E; de Vos, N; Thompson, A D et al. (1995) Chromosome 16 microdeletion in a patient with juvenile neuronal ceroid lipofuscinosis (Batten disease). Am J Hum Genet 56:663-8

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