Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS030428-06
Application #
2268406
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1991-09-30
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Gomez-Isla, T; Wasco, W; Pettingell, W P et al. (1997) A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes. Ann Neurol 41:809-13
Kovacs, D M; Wasco, W; Witherby, J et al. (1995) The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. Hum Mol Genet 4:1527-33
Kim, T W; Wu, K; Xu, J L et al. (1995) Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density. Brain Res Mol Brain Res 32:36-44
Bush, A I; Pettingell Jr, W H; de Paradis, M et al. (1994) The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. J Biol Chem 269:26618-21
Bush, A I; Pettingell, W H; Multhaup, G et al. (1994) Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265:1464-7
Tanzi, R E; Wenniger, J J; Hyman, B T (1993) Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. Brain Res Mol Brain Res 18:246-52
Wasco, W; Brook, J D; Tanzi, R E (1993) The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19. Genomics 15:237-9
Pericak-Vance, M A; St George-Hyslop, P H; Gaskell Jr, P C et al. (1993) Linkage analysis in familial Alzheimer disease: description of the Duke and Boston data sets. Genet Epidemiol 10:361-4
Wasco, W; Gurubhagavatula, S; Paradis, M D et al. (1993) Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet 5:95-100
Tanzi, R; Gaston, S; Bush, A et al. (1993) Genetic heterogeneity of gene defects responsible for familial Alzheimer disease. Genetica 91:255-63

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