Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS030537-04
Application #
2268490
Study Section
Neurology C Study Section (NEUC)
Program Officer
Baughman, Robert W
Project Start
1993-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1997-12-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Allegheny-Singer Research Institute
Department
Type
DUNS #
033098401
City
Pittsburgh
State
PA
Country
United States
Zip Code
15212

  Publications

Wang, X H; Zhu, W J; Corsi, L et al. (1998) Chronic dizocilpine (MK-801) reversibly delays GABA(A) receptor maturation in cerebellar granule neurons in vitro. J Neurochem 71:693-704
Grayson, D R; Zhu, W; Harris, B T et al. (1998) Differentially expressed GABAA-receptor subunits result in structurally and functionally receptor assemblies following excitatory afferent synaptic transmission. Perspect Dev Neurobiol 5:193-205
Ikonomovic, S; Kharlamov, E; Manev, H et al. (1997) GABA and NMDA in the prevention of apoptotic-like cell death in vitro. Neurochem Int 31:283-90
Homanics, G E; Ferguson, C; Quinlan, J J et al. (1997) Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol Pharmacol 51:588-96
Zheng, T M; Caruncho, H J; Zhu, W J et al. (1996) Chronic flumazenil alters GABA(A) receptor subunit mRNA expression, translation product assembly and channel function in neuronal cultures. J Pharmacol Exp Ther 277:525-33
Zhu, W J; Wang, J F; Vicini, S et al. (1996) Alpha 6 and gamma 2 subunit antisense oligodeoxynucleotides alter gamma-aminobutyric acid receptor pharmacology in cerebellar granule neurons. Mol Pharmacol 50:23-33
Harris, B T; Costa, E; Grayson, D R (1995) Exposure of neuronal cultures to K+ depolarization or to N-methyl-D-aspartate increases the transcription of genes encoding the alpha 1 and alpha 5 GABAA receptor subunits. Brain Res Mol Brain Res 28:338-42
Kharlamov, E; Cagnoli, C M; Atabay, C et al. (1995) Opposite effect of protein synthesis inhibitors on potassium deficiency-induced apoptotic cell death in immature and mature neuronal cultures. J Neurochem 65:1395-8
Zhu, W J; Vicini, S; Harris, B T et al. (1995) NMDA-mediated modulation of gamma-aminobutyric acid type A receptor function in cerebellar granule neurons. J Neurosci 15:7692-701
Manev, H; Cagnoli, C M; Atabay, C et al. (1995) Neuronal apoptosis in an in vitro model of photochemically induced oxidative stress. Exp Neurol 133:198-206

Showing the most recent 10 out of 13 publications