The aim of this application is the elucidation of the roles of potential key elements in mechanisms of synaptic vesicle fusion, recycling and synaptic remodeling. This will be accomplished with two sets of studies connected by their involvement in the membrane traffic of synaptic terminals. The first set of studies focuses on the interaction between the synaptic vesicle protein, synaptotagmin, and the presynaptic proteins, the neurexins, as a mechanism for docking and fusion. The second set of studies focuses on two novel proteins of 47 and 49 kD that bind a snake venom toxin, taipoxin, that blocks synaptic vesicle recycling. The investigators hypothesize that these two proteins are directly involved with uptake of synaptic material that may be part of a mechanism for synaptic remodeling.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS030541-07
Application #
2676686
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Program Officer
Talley, Edmund M
Project Start
1992-04-01
Project End
2000-02-29
Budget Start
1997-11-01
Budget End
2000-02-29
Support Year
7
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195