Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS031427-04
Application #
2269351
Study Section
Neurology C Study Section (NEUC)
Program Officer
Kerza-Kwiatecki, a P
Project Start
1992-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1997-11-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Wong, T C; Yant, S; Harder, B J et al. (1997) The cytoplasmic domains of complement regulatory protein CD46 interact with multiple kinases in macrophages. J Leukoc Biol 62:892-900
Yant, S; Hirano, A; Wong, T C (1997) Identification of a cytoplasmic Tyr-X-X-Leu motif essential for down regulation of the human cell receptor CD46 in persistent measles virus infection. J Virol 71:766-70
Hirano, A; Yant, S; Iwata, K et al. (1996) Human cell receptor CD46 is down regulated through recognition of a membrane-proximal region of the cytoplasmic domain in persistent measles virus infection. J Virol 70:6929-36
Gombart, A F; Hirano, A; Wong, T C (1995) Nucleoprotein phosphorylated on both serine and threonine is preferentially assembled into the nucleocapsids of measles virus. Virus Res 37:63-73
Watanabe, M; Hirano, A; Stenglein, S et al. (1995) Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus. J Virol 69:3206-10
Watanabe, M; Wang, A; Sheng, J et al. (1995) Delayed activation of altered fusion glycoprotein in a chronic measles virus variant that causes subacute sclerosing panencephalitis. J Neurovirol 1:412-23
Chen, Z; Hirano, A; Wong, T C (1995) Isolation and characterization of intranuclear ribonucleoprotein complexes associated with double-stranded RNA adenosine deaminase from brain cells: implications for RNA-editing and hypermutation of viral RNA in the CNS. J Neurovirol 1:295-306
Watanabe, M; Wang, A; Sheng, J et al. (1995) Delayed activation of altered fusion glycoprotein in a chronic measles virus variant that causes subacute sclerosing panencephalitis. J Neurovirol 1:177-88
Gombart, A F; Hirano, A; Wong, T C (1993) Conformational maturation of measles virus nucleocapsid protein. J Virol 67:4133-41