Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS031885-03
Application #
2269835
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1994-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Biochemistry
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
D'Souza, Brendan; Meloty-Kapella, Laurence; Weinmaster, Gerry (2010) Canonical and non-canonical Notch ligands. Curr Top Dev Biol 92:73-129
Bozkulak, Esra Cagavi; Weinmaster, Gerry (2009) Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Mol Cell Biol 29:5679-95
Nichols, James T; Miyamoto, Alison; Weinmaster, Gerry (2007) Notch signaling--constantly on the move. Traffic 8:959-69
Nichols, James T; Miyamoto, Alison; Olsen, Samantha L et al. (2007) DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. J Cell Biol 176:445-58
Miyamoto, Alison; Lau, Rhiana; Hein, Patrick W et al. (2006) Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. J Biol Chem 281:10089-97
Yang, Liang-Tung; Nichols, James T; Yao, Christine et al. (2005) Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell 16:927-42
Nehring, Leslie C; Miyamoto, Alison; Hein, Patrick W et al. (2005) The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface. J Biol Chem 280:20349-55
Ladi, Ena; Nichols, James T; Ge, Weihong et al. (2005) The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol 170:983-92
Hicks, Carol; Ladi, Ena; Lindsell, Claire et al. (2002) A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling. J Neurosci Res 68:655-67
Zhang, J; Chen, H; Weinmaster, G et al. (2001) Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. J Virol 75:2946-56

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