|
Khodr, Christina E; Becerra, Amanda; Han, Ye et al. (2014) Targeting alpha-synuclein with a microRNA-embedded silencing vector in the rat substantia nigra: positive and negative effects. Brain Res 1550:47-60
|
|
Khodr, Christina E; Pedapati, Jyothi; Han, Ye et al. (2012) Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra. Dev Neurobiol 72:906-17
|
|
Khodr, Christina E; Sapru, Mohan K; Pedapati, Jyothi et al. (2011) An ?-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons. Brain Res 1395:94-107
|
|
Han, Y; Chang, Q A; Virag, T et al. (2010) Lack of humoral immune response to the tetracycline (Tet) activator in rats injected intracranially with Tet-off rAAV vectors. Gene Ther 17:616-25
|
|
Ebert, Allison D; Hann, Hoo Jae; Bohn, Martha C (2008) Progressive degeneration of dopamine neurons in 6-hydroxydopamine rat model of Parkinson's disease does not involve activation of caspase-9 and caspase-3. J Neurosci Res 86:317-25
|
|
Sapru, Mohan K; Yates, Jonathan W; Hogan, Shea et al. (2006) Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAi. Exp Neurol 198:382-90
|
|
Ebert, Allison D; Chen, Feng; He, Xiaolong et al. (2005) A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo. Exp Neurol 191 Suppl 1:S80-94
|
|
Jiang, L; Rampalli, S; George, D et al. (2004) Tight regulation from a single tet-off rAAV vector as demonstrated by flow cytometry and quantitative, real-time PCR. Gene Ther 11:1057-67
|
|
Chen, Feng; Chang, Roger; Trivedi, Marcus et al. (2003) Caspase proteolysis of desmin produces a dominant-negative inhibitor of intermediate filaments and promotes apoptosis. J Biol Chem 278:6848-53
|
|
Gamblin, T Chris; Chen, Feng; Zambrano, Angara et al. (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc Natl Acad Sci U S A 100:10032-7
|
Showing the most recent 10 out of 25 publications
