Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS032122-03
Application #
2270102
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1994-04-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wistar Institute
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Wiemelt, A P; Lehtinen, M; McMorris, F A (2001) Agonists calcitonin, corticotropin-releasing hormone, and vasoactive intestinal peptide, but not prostaglandins or beta-adrenergic agonists, elevate cyclic adenosine monophosphate levels in oligodendroglial cells. J Neurosci Res 65:165-72
Shen, S; Wiemelt, A P; McMorris, F A et al. (1999) Retinal ganglion cells lose trophic responsiveness after axotomy. Neuron 23:285-95
Hanson Jr, M G; Shen, S; Wiemelt, A P et al. (1998) Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. J Neurosci 18:7361-71
Mewar, R; McMorris, F A (1997) Expression of insulin-like growth factor-binding protein messenger RNAs in developing rat oligodendrocytes and astrocytes. J Neurosci Res 50:721-8
Wiemelt, A P; Engleka, M J; Skorupa, A F et al. (1997) Immunochemical visualization and quantitation of cyclic AMP in single cells. J Biol Chem 272:31489-95
McMorris, F A; McKinnon, R D (1996) Regulation of oligodendrocyte development and CNS myelination by growth factors: prospects for therapy of demyelinating disease. Brain Pathol 6:313-29
Vemuri, G S; McMorris, F A (1996) Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signaling for survival. Development 122:2529-37
Shinar, Y; McMorris, F A (1995) Developing oligodendroglia express mRNA for insulin-like growth factor-I, a regulator of oligodendrocyte development. J Neurosci Res 42:516-27