Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS032290-03
Application #
2270356
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1994-08-08
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Townsend, Matthew; Liu, Yudong; Constantine-Paton, Martha (2004) Retina-driven dephosphorylation of the NR2A subunit correlates with faster NMDA receptor kinetics at developing retinocollicular synapses. J Neurosci 24:11098-107
Colonnese, Matthew T; Shi, Jian; Constantine-Paton, Martha (2003) Chronic NMDA receptor blockade from birth delays the maturation of NMDA currents, but does not affect AMPA/kainate currents. J Neurophysiol 89:57-68
Townsend, Matthew; Yoshii, Akira; Mishina, M et al. (2003) Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Proc Natl Acad Sci U S A 100:1340-5
Yoshii, Akira; Sheng, Morgan H; Constantine-Paton, Martha (2003) Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons. Proc Natl Acad Sci U S A 100:1334-9
Shi, J; Aamodt, S M; Townsend, M et al. (2001) Developmental depression of glutamate neurotransmission by chronic low-level activation of NMDA receptors. J Neurosci 21:6233-44
Shi, J; Townsend, M; Constantine-Paton, M (2000) Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents. Neuron 28:103-14
Aamodt, S M; Shi, J; Colonnese, M T et al. (2000) Chronic NMDA exposure accelerates development of GABAergic inhibition in the superior colliculus. J Neurophysiol 83:1580-91
Shi, J; Aamodt, S M; Constantine-Paton, M (1997) Temporal correlations between functional and molecular changes in NMDA receptors and GABA neurotransmission in the superior colliculus. J Neurosci 17:6264-76
Scheetz, A J; Prusky, G T; Constantine-Paton, M (1996) Chronic NMDA receptor antagonism during retinotopic map formation depresses CaM kinase II differentiation in rat superior colliculus. Eur J Neurosci 8:1322-8