The Golli-mbp gene encodes two families of proteins, the Golli proteins and the myelin basic proteins. The overall goal of this application is to identify the genetic regulatory elements that govern specificity in the regulation of transcription start sites for this gene in oligodendrocytes and neurons in the nervous system and in macrophages and other cells in the immune system. A part of this application is to use a promoter element, as well as transgenic mice expressing a reporter gene under its control to investigate the developmental biology of these cortical pioneer neurons and the fate of the subplate that they form.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
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Neurology C Study Section (NEUC)
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Behar, Toby
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University of California Los Angeles
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
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Smith, Graham S T; Paez, Pablo M; Spreuer, Vilma et al. (2011) Classical 18.5-and 21.5-kDa isoforms of myelin basic protein inhibit calcium influx into oligodendroglial cells, in contrast to golli isoforms. J Neurosci Res 89:467-80
Paez, Pablo M; Fulton, Daniel J; Spreur, Vilma et al. (2010) Multiple kinase pathways regulate voltage-dependent Ca2+ influx and migration in oligodendrocyte precursor cells. J Neurosci 30:6422-33
Fisher, Robin; Xie, Yuan-Yun (2010) Growth defects in the dorsal pallium after genetically targeted ablation of principal preplate neurons and neuroblasts: a morphometric analysis. ASN Neuro 2:e00046
Xie, Yuan-Yun; Jacobs, Erin; Fisher, Robin (2009) Targeted ablation and reorganization of the principal preplate neurons and their neuroblasts identified by golli promoter transgene expression in the neocortex of mice. ASN Neuro 1:
Paez, Pablo M; Fulton, Daniel J; Spreuer, Vilma et al. (2009) Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx. J Neurosci 29:6663-76
Jacobs, Erin C; Campagnoni, Celia; Kampf, Kathy et al. (2007) Visualization of corticofugal projections during early cortical development in a tau-GFP-transgenic mouse. Eur J Neurosci 25:17-30
Paez, Pablo M; Spreuer, Vilma; Handley, Vance et al. (2007) Increased expression of golli myelin basic proteins enhances calcium influx into oligodendroglial cells. J Neurosci 27:12690-9
Feng, Ji-Ming; Hu, Yanhong K; Xie, Lai-Hua et al. (2006) Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity 24:717-27
Fernandes, Augustine O; Campagnoni, Celia W; Kampf, Kathy et al. (2004) Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system. J Neurosci Res 75:461-71
Feng, Ji-Ming; Fernandes, Augustine O; Campagnoni, Celia W et al. (2004) The golli-myelin basic protein negatively regulates signal transduction in T lymphocytes. J Neuroimmunol 152:57-66

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