Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS033273-02
Application #
2271973
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1995-06-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Organized Research Units
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Leighton, Barbara H; Seal, Rebecca P; Watts, Spencer D et al. (2006) Structural rearrangements at the translocation pore of the human glutamate transporter, EAAT1. J Biol Chem 281:29788-96
Shimamoto, Keiko; Sakai, Ryuichi; Takaoka, Kiyo et al. (2004) Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters. Mol Pharmacol 65:1008-15
Cheng, Chialin; Glover, Greta; Banker, Gary et al. (2002) A novel sorting motif in the glutamate transporter excitatory amino acid transporter 3 directs its targeting in Madin-Darby canine kidney cells and hippocampal neurons. J Neurosci 22:10643-52
Leighton, Barbara H; Seal, Rebecca P; Shimamoto, Keiko et al. (2002) A hydrophobic domain in glutamate transporters forms an extracellular helix associated with the permeation pathway for substrates. J Biol Chem 277:29847-55
Shigeri, Y; Shimamoto, K; Yasuda-Kamatani, Y et al. (2001) Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5). J Neurochem 79:297-302
Seal, R P; Leighton, B H; Amara, S G (2000) A model for the topology of excitatory amino acid transporters determined by the extracellular accessibility of substituted cysteines. Neuron 25:695-706
Seal, R P; Amara, S G (1998) A reentrant loop domain in the glutamate carrier EAAT1 participates in substrate binding and translocation. Neuron 21:1487-98
Eliasof, S; Arriza, J L; Leighton, B H et al. (1998) Localization and function of five glutamate transporters cloned from the salamander retina. Vision Res 38:1443-54
Amara, S G; Sonders, M S (1998) Neurotransmitter transporters as molecular targets for addictive drugs. Drug Alcohol Depend 51:87-96
Fairman, W A; Sonders, M S; Murdoch, G H et al. (1998) Arachidonic acid elicits a substrate-gated proton current associated with the glutamate transporter EAAT4. Nat Neurosci 1:105-13

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