Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS033687-02
Application #
2272632
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1995-08-15
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Surgery
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Yates, J R; Gay, E A; Heyes, M P et al. (2014) Effects of methylprednisolone and 4-chloro-3-hydroxyanthranilic acid in experimental spinal cord injury in the guinea pig appear to be mediated by different and potentially complementary mechanisms. Spinal Cord 52:662-6
Luo, Jian; Uchida, Koji; Shi, Riyi (2005) Accumulation of acrolein-protein adducts after traumatic spinal cord injury. Neurochem Res 30:291-5
Luo, Jian; Borgens, Richard; Shi, Riyi (2004) Polyethylene glycol improves function and reduces oxidative stress in synaptosomal preparations following spinal cord injury. J Neurotrauma 21:994-1007
Luo, Jian; Shi, Riyi (2004) Diffusive oxidative stress following acute spinal cord injury in guinea pigs and its inhibition by polyethylene glycol. Neurosci Lett 359:167-70
Luo, Jian; Shi, Riyi (2004) Acrolein induces axolemmal disruption, oxidative stress, and mitochondrial impairment in spinal cord tissue. Neurochem Int 44:475-86
Shi, R; Luo, J; Peasley, M (2002) Acrolein inflicts axonal membrane disruption and conduction loss in isolated guinea-pig spinal cord. Neuroscience 115:337-40
Luo, Jian; Borgens, Richard; Shi, Riyi (2002) Polyethylene glycol immediately repairs neuronal membranes and inhibits free radical production after acute spinal cord injury. J Neurochem 83:471-80
Shi, R; Asano, T; Vining, N C et al. (2000) Control of membrane sealing in injured mammalian spinal cord axons. J Neurophysiol 84:1763-9
LoPachin, R M; Gaughan, C L; Lehning, E J et al. (1999) Experimental spinal cord injury: spatiotemporal characterization of elemental concentrations and water contents in axons and neuroglia. J Neurophysiol 82:2143-53
Nygren, A; Halter, J A (1999) A general approach to modeling conduction and concentration dynamics in excitable cells of concentric cylindrical geometry. J Theor Biol 199:329-58

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