Endogenous Dynorphin Opioids and Temporal Lobe Epilepsy

Chavkin, Charles

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 5R01NS033898-02
• Application #: 2272926
• Study Section: Neurological Sciences Subcommittee 1 (NLS)
• Project Start: 1995-09-30
• Project End: 1999-09-29
• Budget Start: 1996-09-30
• Budget End: 1997-09-29
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: University of Washington
• Department: Pharmacology
• Type: Schools of Medicine
• DUNS #: 135646524
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98195

Publications

Crowder, K M; Gunther, J M; Jones, T A et al. (1999) Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A). Proc Natl Acad Sci U S A 96:15268-73

Bausch, S B; Esteb, T M; Terman, G W et al. (1998) Administered and endogenously released kappa opioids decrease pilocarpine-induced seizures and seizure-induced histopathology. J Pharmacol Exp Ther 284:1147-55

Simmons, M L; Terman, G W; Chavkin, C (1997) Spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. J Neurophysiol 78:1860-8

Bausch, S B; Chavkin, C (1997) Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation. J Neurosci 17:477-92