Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS034071-02
Application #
2273180
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1995-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Sun, Ying; Qi, Xiaoyang; Grabowski, Gregory A (2003) Saposin C is required for normal resistance of acid beta-glucosidase to proteolytic degradation. J Biol Chem 278:31918-23
You, Hong Xing; Qi, Xiaoyang; Grabowski, Gregory A et al. (2003) Phospholipid membrane interactions of saposin C: in situ atomic force microscopic study. Biophys J 84:2043-57
Sun, Ying; Witte, David P; Jin, Peng et al. (2003) Analyses of temporal regulatory elements of the prosaposin gene in transgenic mice. Biochem J 370:557-66
Wang, Ying; Grabowski, Gregory A; Qi, Xiaoyang (2003) Phospholipid vesicle fusion induced by saposin C. Arch Biochem Biophys 415:43-53
Qi, X; Grabowski, G A (2001) Molecular and cell biology of acid beta-glucosidase and prosaposin. Prog Nucleic Acid Res Mol Biol 66:203-39
Jin, P; Sun, Y; Grabowski, G A (2001) In vivo roles of RORalpha and Sp4 in the regulation of murine prosaposin gene. DNA Cell Biol 20:781-9
Qi, X; Grabowski, G A (2001) Differential membrane interactions of saposins A and C: implications for the functional specificity. J Biol Chem 276:27010-7
Sun, Y; Jin, P; Witte, D P et al. (2000) Prosaposin: promoter analysis and central-nervous-system-preferential elements for expression in vivo. Biochem J 352 Pt 2:549-56
Chang, M H; Bindloss, C A; Grabowski, G A et al. (2000) Saposins A, B, C, and D in plasma of patients with lysosomal storage disorders. Clin Chem 46:167-74
Qi, X; Kondoh, K; Krusling, D et al. (1999) Conformational and amino acid residue requirements for the saposin C neuritogenic effect. Biochemistry 38:6284-91

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