Eicosanoid Mechanisms Initiating Neurogenic Inflammation

Vasko, Michael R.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 5R01NS034159-02
• Application #: 2273298
• Study Section: Neurological Sciences Subcommittee 1 (NLS)
• Program Officer: Kitt, Cheryl A
• Project Start: 1995-05-01
• Project End: 1999-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Indiana University-Purdue University at Indianapolis
• Department: Pharmacology
• Type: Schools of Medicine
• DUNS #: 005436803
• City: Indianapolis
• State: IN
• Country: United States
• Zip Code: 46202

Publications

Malty, Ramy Habashy; Hudmon, Andy; Fehrenbacher, Jill C et al. (2016) Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A. J Neuroinflammation 13:181

Shariati, Behzad; Thompson, Eric L; Nicol, Grant D et al. (2016) Epac activation sensitizes rat sensory neurons through activation of Ras. Mol Cell Neurosci 70:54-67

Vasko, Michael R; Guo, Chunlu; Kelley, Mark R (2005) The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. DNA Repair (Amst) 4:367-79

Fehrenbacher, Jill C; Burkey, Thomas H; Nicol, Grant D et al. (2005) Tumor necrosis factor alpha and interleukin-1beta stimulate the expression of cyclooxygenase II but do not alter prostaglandin E2 receptor mRNA levels in cultured dorsal root ganglia cells. Pain 113:113-22

Fehrenbacher, Jill C; Taylor, Charles P; Vasko, Michael R (2003) Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C. Pain 105:133-41

Huang, H; Wu, X; Nicol, G D et al. (2003) ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors. J Pharmacol Exp Ther 306:1137-44

Wang, XiaoXia; Butowt, Rafal; Vasko, Michael R et al. (2002) Mechanisms of the release of anterogradely transported neurotrophin-3 from axon terminals. J Neurosci 22:931-45

Southall, M D; Bolyard, L A; Vasko, M R (2002) Twenty-four hour exposure to prostaglandin downregulates prostanoid receptor binding but does not alter PGE(2)-mediated sensitization of rat sensory neurons. Pain 96:285-96

Richardson, Jennelle Durnett; Vasko, Michael R (2002) Cellular mechanisms of neurogenic inflammation. J Pharmacol Exp Ther 302:839-45

Southall, M D; Vasko, M R (2001) Prostaglandin receptor subtypes, EP3C and EP4, mediate the prostaglandin E2-induced cAMP production and sensitization of sensory neurons. J Biol Chem 276:16083-91