Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS034819-01
Application #
2274123
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Turley, Danielle M; Miller, Stephen D (2010) Prospects for antigen-specific tolerance based therapies for the treatment of multiple sclerosis. Results Probl Cell Differ 51:217-35
Podojil, Joseph R; Miller, Stephen D (2009) Molecular mechanisms of T-cell receptor and costimulatory molecule ligation/blockade in autoimmune disease therapy. Immunol Rev 229:337-55
Podojil, Joseph R; Miller, Stephen D (2009) Cross-linking of CD80 on CD4+ T cells activates a calcium-dependent signaling pathway. J Immunol 182:766-73
Podojil, Joseph R; Turley, Danielle M; Miller, Stephen D (2008) Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease. Adv Exp Med Biol 640:234-51
Podojil, Joseph R; Kohm, Adam P; Miller, Stephen D (2006) CD4+ T cell expressed CD80 regulates central nervous system effector function and survival during experimental autoimmune encephalomyelitis. J Immunol 177:2948-58
Kohm, Adam P; Podojil, Joseph R; Williams, Julie S et al. (2005) CD28 regulates glucocorticoid-induced TNF receptor family-related gene expression on CD4+ T cells via IL-2-dependent mechanisms. Cell Immunol 235:56-64
Kohm, Adam P; Williams, Julie S; Bickford, Allison L et al. (2005) Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis. J Immunol 174:4525-34
Eagar, Todd N; Turley, Danielle M; Padilla, Josette et al. (2004) CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance. J Immunol 172:7442-50
Howard, Laurence M; Neville, Katherine L; Haynes, Lia M et al. (2003) CD154 blockade results in transient reduction in Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Virol 77:2247-50
Theien, Bradley E; Vanderlugt, Carol L; Nickerson-Nutter, Cheryl et al. (2003) Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE. Blood 102:4464-71

Showing the most recent 10 out of 28 publications