Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS035205-01
Application #
2274527
Study Section
Special Emphasis Panel (ZRG1-NLS-3 (01))
Project Start
1996-05-01
Project End
2001-03-31
Budget Start
1996-05-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albany Medical College
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12208
Zhang, Huaqiu; Cao, H James; Kimelberg, Harold K et al. (2011) Volume regulated anion channel currents of rat hippocampal neurons and their contribution to oxygen-and-glucose deprivation induced neuronal death. PLoS One 6:e16803
Zhang, Huaqiu; Xie, Minjie; Schools, Gary P et al. (2009) Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model. Brain Res 1247:196-211
Zhang, Huaqiu; Schools, Gary P; Lei, Ting et al. (2008) Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation. Exp Neurol 212:44-52
Haskew-Layton, Renee E; Rudkouskaya, Alena; Jin, Yiqiang et al. (2008) Two distinct modes of hypoosmotic medium-induced release of excitatory amino acids and taurine in the rat brain in vivo. PLoS One 3:e3543
Zhang, Yonghua; Zhang, Huaqiu; Feustel, Paul J et al. (2008) DCPIB, a specific inhibitor of volume regulated anion channels (VRACs), reduces infarct size in MCAo and the release of glutamate in the ischemic cortical penumbra. Exp Neurol 210:514-20
Kimelberg, Harold K (2008) Tamoxifen as a powerful neuroprotectant in experimental stroke and implications for human stroke therapy. Recent Pat CNS Drug Discov 3:104-8
Xie, Minjie; Wang, Wei; Kimelberg, Harold K et al. (2008) Oxygen and glucose deprivation-induced changes in astrocyte membrane potential and their underlying mechanisms in acute rat hippocampal slices. J Cereb Blood Flow Metab 28:456-67
Zhang, Yonghua; Milatovic, Dejan; Aschner, Michael et al. (2007) Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity. Exp Neurol 204:819-27
Kimelberg, Harold K (2007) Supportive or information-processing functions of the mature protoplasmic astrocyte in the mammalian CNS? A critical appraisal. Neuron Glia Biol 3:181-189
Abdullaev, Iskandar F; Rudkouskaya, Alena; Schools, Gary P et al. (2006) Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes. J Physiol 572:677-89

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