This application is focussed on the signal transduction of dopamine. Recently, the applicant and several other investigators have demonstrated that some actions of dopamine in the brain may be mediated through the phosphoinositide signaling cascade rather than the classic adenylyl cyclase system. The goal of the proposed project will be to elucidate the mode and mechanisms of functional regulation in the phospholipase C coupled dopamine system. There are three primary questions to be addressed by the experiments: (1) Where in the brain does dopamine signal through the phospholipase C pathway?; (2) Which G-proteins mediate dopamine receptor coupling to phospholipase C?, and (3) How is the efficacy of dopamine receptor coupling to phospholipase C regulated?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS035571-02
Application #
2460661
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Program Officer
Oliver, Eugene J
Project Start
1996-09-01
Project End
2000-07-31
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201