Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS035734-01
Application #
2274961
Study Section
AIDS and Related Research Study Section 7 (ARRG)
Project Start
1996-08-01
Project End
1999-04-30
Budget Start
1996-08-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Agopian, Kristin; Wei, Bangdong L; Garcia, J Victor et al. (2007) CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable. Virology 358:119-35
Agopian, Kristin; Wei, Bangdong L; Garcia, J Victor et al. (2006) A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2. J Virol 80:3050-61
Ancuta, Petronela; Wang, Jianbin; Gabuzda, Dana (2006) CD16+ monocytes produce IL-6, CCL2, and matrix metalloproteinase-9 upon interaction with CX3CL1-expressing endothelial cells. J Leukoc Biol 80:1156-64
Wang, Jianbin; Gabuzda, Dana (2006) Reconstitution of human immunodeficiency virus-induced neurodegeneration using isolated populations of human neurons, astrocytes, and microglia and neuroprotection mediated by insulin-like growth factors. J Neurovirol 12:472-91
Dunfee, Rebecca; Thomas, Elaine R; Gorry, Paul R et al. (2006) Mechanisms of HIV-1 neurotropism. Curr HIV Res 4:267-78
Gorry, Paul R; Churchill, Melissa; Crowe, Suzanne M et al. (2005) Pathogenesis of macrophage tropic HIV-1. Curr HIV Res 3:53-60
Holm, Geoffrey H; Gabuzda, Dana (2005) Distinct mechanisms of CD4+ and CD8+ T-cell activation and bystander apoptosis induced by human immunodeficiency virus type 1 virions. J Virol 79:6299-311
Wang, Jianbin; Babcock, Gregory J; Choe, Hyeryun et al. (2004) N-linked glycosylation in the CXCR4 N-terminus inhibits binding to HIV-1 envelope glycoproteins. Virology 324:140-50
Holm, Geoffrey H; Zhang, Chengsheng; Gorry, Paul R et al. (2004) Apoptosis of bystander T cells induced by human immunodeficiency virus type 1 with increased envelope/receptor affinity and coreceptor binding site exposure. J Virol 78:4541-51
Bobardt, Michael D; Salmon, Patrick; Wang, Lianchun et al. (2004) Contribution of proteoglycans to human immunodeficiency virus type 1 brain invasion. J Virol 78:6567-84

Showing the most recent 10 out of 22 publications