The long-term objective of this study is to understand the local population interactions in neocortex, an important process for both normal cortical functioning and for neurological disorders such as epilepsy. Our approach is to examine the spatio-temporal patterns and cellular properties of population activity in intrinsic cortical circuits. We hypothesize that one basic form of population activation in neocortex is the dynamically organized multi-neuronal ensemble. In our previous study we found a local co-activation in adult cortical slices which is related to the activity patterns in the cortex. This kind of co- activation is dynamically organized, all-or-none population event with an asynchronized, low density of spikes. It could be evoked by a proper stimulation or spontaneously occurred as a propagating activation during 7 to 10 Hz oscillations. This proposal will utilize voltage-sensitive dye imaging and electrophysiological methods to further study the spatio-temporal dynamics and neuronal activities of this cortical population event. There are four specific aims.
Aim 1 will examine the proper stimulation patterns which can evoke or interact with this activity, and explore whether this activity can commonly occur in different cortical areas.
Aim 2 will study the network and cellular mechanisms which sustain this co-activation.
Aim 3 will study propagation of this activity and the interactions with the cortical columnar organization.
Aim 4 will study the neuronal activity within this dynamically organized population event. This study will increase our knowledge about the cortical population activities related to the input pattern and intrinsic activities in cortex during normal and pathological conditions.
| Huang, Ying; Yoon, Kristopher; Ko, Ho et al. (2016) 5-HT3a Receptors Modulate Hippocampal Gamma Oscillations by Regulating Synchrony of Parvalbumin-Positive Interneurons. Cereb Cortex 26:576-85 |
| Liang, Jianmin; Xu, Weifeng; Geng, Xinling et al. (2015) Monitoring Population Membrane Potential Signals from Neocortex. Adv Exp Med Biol 859:171-96 |
| Baker, Bradley; Gao, Xin; Wolff, Brian S et al. (2015) Voltage-Sensitive Dye Imaging of Population Signals in Brain Slices. Cold Spring Harb Protoc 2015:995-9 |
| Takagaki, Kentaroh; Zhang, Chuan; Wu, Jian-Young et al. (2011) Flow detection of propagating waves with temporospatial correlation of activity. J Neurosci Methods 200:207-18 |
| Huang, Xiaoying; Xu, Weifeng; Liang, Jianmin et al. (2010) Spiral wave dynamics in neocortex. Neuron 68:978-990 |
| Takagaki, Kentaroh; Zhang, Chuan; Wu, Jian-Young et al. (2008) Crossmodal propagation of sensory-evoked and spontaneous activity in the rat neocortex. Neurosci Lett 431:191-6 |
| Wu, Jian-Young; Xiaoying Huang; Chuan Zhang (2008) Propagating waves of activity in the neocortex: what they are, what they do. Neuroscientist 14:487-502 |
| Arai, Yoshiyasu; Mentis, George Z; Wu, Jiang-Young et al. (2007) Ventrolateral origin of each cycle of rhythmic activity generated by the spinal cord of the chick embryo. PLoS One 2:e417 |
| Lippert, Michael T; Takagaki, Kentaroh; Xu, Weifeng et al. (2007) Methods for voltage-sensitive dye imaging of rat cortical activity with high signal-to-noise ratio. J Neurophysiol 98:502-12 |
| Xu, Weifeng; Huang, Xiaoying; Takagaki, Kentaroh et al. (2007) Compression and reflection of visually evoked cortical waves. Neuron 55:119-29 |
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