Neural mechanisms of human memory are investigated utilizing a unique opportunity, craniotomy where the patient is awake under local anesthesia for a portion of the operation. During the portion of these operation, neural activity occurring with memory measures is recorded by extracellular microelectrodes in human lateral temporal and entorhinal cortex, and hippocampus. Multiple aspects or memory are evaluated during those recordings, including long-term semantic, recent explicit post-distractional, working, and implicit memory and recall and recognition modes of retrieval. These various aspects of memory are assessed for three types of verbal material, visually presented names of objects and words and auditory words. based on our previous observation, we expect to identify neurons related to the various aspects of memory in lateral temporal cortex, as well as more medial temporal structures. Individual neurons will be related to a specific aspect of memory, and for the same aspect of memory, to a specific type of verbal material. Each aspect of memory for each type of verbal material has separate neural systems in temporal lobe. This study, then, will more clearly define the subdivisions of human verbal memory and establish some of the changes in neural activity occurring with them.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS036527-02
Application #
2685781
Study Section
Neurology A Study Section (NEUA)
Program Officer
Jacobs, Margaret
Project Start
1997-04-01
Project End
2002-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Washington
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Ojemann, George A; Schoenfield-McNeill, Julie; Corina, David (2009) The roles of human lateral temporal cortical neuronal activity in recent verbal memory encoding. Cereb Cortex 19:197-205
Lucas 2nd, Timothy H; McKhann 2nd, Guy M; Ojemann, George A (2004) Functional separation of languages in the bilingual brain: a comparison of electrical stimulation language mapping in 25 bilingual patients and 117 monolingual control patients. J Neurosurg 101:449-57
Ojemann, George A; Schoenfield-McNeill, Julie; Corina, David (2004) Different neurons in different regions of human temporal lobe distinguish correct from incorrect identification or memory. Neuropsychologia 42:1383-93
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Ojemann, G A; Schoenfield-McNeill, J; Corina, D P (2002) Anatomic subdivisions in human temporal cortical neuronal activity related to recent verbal memory. Nat Neurosci 5:64-71
Ojemann, G A; Schoenfield-McNeill, J (1999) Activity of neurons in human temporal cortex during identification and memory for names and words. J Neurosci 19:5674-82
Ojemann, G A; Schoenfield-McNeill, J (1998) Neurons in human temporal cortex active with verbal associative learning. Brain Lang 64:317-27