Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS036548-02
Application #
6187804
Study Section
Special Emphasis Panel (ZRG1-BDCN-3 (01))
Program Officer
Heemskerk, Jill E
Project Start
1999-06-01
Project End
2003-05-30
Budget Start
2000-05-31
Budget End
2001-05-30
Support Year
2
Fiscal Year
2000
Total Cost
$192,104
Indirect Cost

  Institution

Name
University of California Irvine
Department
Neurology
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Yin, Hong Z; Yu, Stephen; Hsu, Cheng-I et al. (2014) Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord. Exp Neurol 261:1-9
Nalbandian, Angèle; Llewellyn, Katrina J; Badadani, Mallikarjun et al. (2013) A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse. Muscle Nerve 47:260-70
Nalbandian, Angèle; Llewellyn, Katrina J; Kitazawa, Masashi et al. (2012) The homozygote VCP(R¹??H/R¹??H) mouse model exhibits accelerated human VCP-associated disease pathology. PLoS One 7:e46308
Yin, H Z; Nalbandian, A; Hsu, C-I et al. (2012) Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice. Cell Death Dis 3:e374
Yin, Hong Z; Weiss, John H (2012) Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures. Brain Res 1448:153-62
Yin, Hong Z; Hsu, Cheng-I; Yu, Stephen et al. (2012) TNF-? triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury. Exp Neurol 238:93-102
Weiss, John H (2011) Ca permeable AMPA channels in diseases of the nervous system. Front Mol Neurosci 4:42
Rossi, Sharyn L; Nistor, Gabriel; Wyatt, Tanya et al. (2010) Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord. PLoS One 5:e11852
Dietz, Robert M; Weiss, John H; Shuttleworth, C William (2009) Contributions of Ca2+ and Zn2+ to spreading depression-like events and neuronal injury. J Neurochem 109 Suppl 1:145-52
Medvedeva, Yuliya V; Lin, Bin; Shuttleworth, C William et al. (2009) Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. J Neurosci 29:1105-14

Showing the most recent 10 out of 22 publications