The broad long-term goal of this project was to develop theories, algorithms, and their portable computer implementations for quantifying object information captured in multidimensional images and to apply them to solve specific biomedical problems. The lack of cost-effective methods with proven precision and accuracy for extracting object information from images remains one of the major impediments in many radiological applications. With this in mind, the applicants proposed: (1) to advance the theory, algorithms, and their efficient computer implementations for detecting and delineating objects in multidimensional, multiparametric images in general, and (2) to apply these methods to the problem of quantifying MS lesions of the brain via MR imagery. The methods proposed in this application are based on a theory relating to definition of objects in images. Since images are by nature fuzzy, the theory considers objects as a set of image elements that """"""""hang-together"""""""" fuzzily. A fuzzy topological concept called fuzzy connectedness is introduced that captures the idea of """"""""hanging-togetherness."""""""" Although the concept is computationally impractical, key theoretical results lead to practical computer algorithms for detecting fuzzy objects in images. MS is an intensively studied disease of the nervous system. Its detection and quantification via MR images has proved critical to the monitoring of this disease and of its response to therapy. However, a practical solution to this problem is still not available. Supported by strong preliminary results, this application proposes practical methods based on fuzzy connectedness for the detection and quantification of MS lesions. The overall hypothesis underlying this research is that the methods resulting from this investigation will be practical, cost-effective, and reliable for quantifying MS lesions with a precision and accuracy that is acceptable for conducting clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS037172-02
Application #
2839436
Study Section
Special Emphasis Panel (ZRG7-DMG (01))
Program Officer
Kerza-Kwiatecki, a P
Project Start
1997-12-01
Project End
2000-11-30
Budget Start
1998-12-01
Budget End
2000-11-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Doty, Richard L; Tourbier, Isabelle A; Pham, Dzung L et al. (2016) Taste dysfunction in multiple sclerosis. J Neurol 263:677-88
Zhuge, Ying; Udupa, Jayaram K; Liu, Jiamin et al. (2009) Image background inhomogeneity correction in MRI via intensity standardization. Comput Med Imaging Graph 33:7-16
Liu, Jiamin; Udupa, Jayaram K; Saha, Punam K et al. (2008) Rigid model-based 3D segmentation of the bones of joints in MR and CT images for motion analysis. Med Phys 35:3637-49
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Liu, Jianguo; Udupa, Jayaram K; Odhner, Dewey et al. (2005) A system for brain tumor volume estimation via MR imaging and fuzzy connectedness. Comput Med Imaging Graph 29:21-34
Lei, Tianhu; Udupa, Jayaram K; Odhner, Dewey et al. (2003) 3DVIEWNIX-AVS: a software package for the separate visualization of arteries and veins in CE-MRA images. Comput Med Imaging Graph 27:351-62
Nyul, Laszlo G; Udupa, Jayaram K; Saha, Punam K (2003) Incorporating a measure of local scale in voxel-based 3-D image registration. IEEE Trans Med Imaging 22:228-37

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