Abstract

This is a proposal to address a variety of biostatistical problems motivated by the use of magnetic resonance neuroimaging (MRN) of brain structure and function in the study of psychiatric and neurological outcomes in healthy and diseased subjects, both young and old.
Research aims i nclude development and refinement of (1) longitudinal data methods for the analysis of data collected from functional activation and structural volumetric studies; (2) flexible methods of analysis of MRN data based on the newly developing field of functional data analysis; (3) efficient, cost-effective design strategies for studies involving multiple outcomes, including MRN; (4) methods to study MRN outcomes as correlates and predictors of disease severity and onset. Empirical data analysis will play a central role in all aims. Data are available from a variety of sources and encompass examples of conventional structural MRN, functional MRN and magnetic resonance spectroscopic neuroimaging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS037483-03
Application #
6165262
Study Section
Special Emphasis Panel (ZRG7-STA (01))
Program Officer
Marler, John R
Project Start
1998-04-01
Project End
2003-02-28
Budget Start
2000-03-01
Budget End
2001-02-28
Support Year
3
Fiscal Year
2000
Total Cost
$98,603
Indirect Cost

  Institution

Name
Mc Lean Hospital (Belmont, MA)
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02478

  Publications

Anderson, J S; Lange, N; Froehlich, A et al. (2010) Decreased left posterior insular activity during auditory language in autism. AJNR Am J Neuroradiol 31:131-9
Forester, Brent P; Berlow, Yosef A; Harper, David G et al. (2010) Age-related changes in brain energetics and phospholipid metabolism. NMR Biomed 23:242-50
Cataldo, Anne M; McPhie, Donna L; Lange, Nicholas T et al. (2010) Abnormalities in mitochondrial structure in cells from patients with bipolar disorder. Am J Pathol 177:575-85
Lange, Nicholas; Dubray, Molly B; Lee, Jee Eun et al. (2010) Atypical diffusion tensor hemispheric asymmetry in autism. Autism Res 3:350-8
Basu, A C; Tsai, G E; Ma, C-L et al. (2009) Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol Psychiatry 14:719-27
Sheth, Archana; Berretta, Sabina; Lange, Nicholas et al. (2008) The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty. Hippocampus 18:169-81
Berretta, Sabina; Pantazopoulos, Harry; Lange, Nicholas (2007) Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia. Biol Psychiatry 62:884-93
Pantazopoulos, Harry; Lange, Nicholas; Baldessarini, Ross J et al. (2007) Parvalbumin neurons in the entorhinal cortex of subjects diagnosed with bipolar disorder or schizophrenia. Biol Psychiatry 61:640-52
Frazier, Jean A; Chiu, Sufen; Breeze, Janis L et al. (2005) Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Am J Psychiatry 162:1256-65
Harezlak, Jaroslaw; Ryan, Louise M; Giedd, Jay N et al. (2005) Individual and population penalized regression splines for accelerated longitudinal designs. Biometrics 61:1037-48

Showing the most recent 10 out of 24 publications