Characterizing the relationship between the structure of the human brain and its function is one of the most important goals in neuroscience today. Medical imaging has been used to gain significant new insights into this relationship through the use of both anatomical and physiological imaging methods. Despite significant recent advances, the current methodology is still limited by the lack of automatic methods for the detailed segmentation, geometric analysis, and labeling of the cerebral cortex. The major goals of the proposed research are to develop fully automated methods to find and mathematically represent the cerebral cortex in volumetric magnetic resonance (MR) images and to automatically identify and label the major sulci and gyri on the cortex using a detailed statistical analysis of cortical geometry. Specifically, we propose to 1) develop and validate methods to find and mathematically represent the cerebral cortex from volumetric MR images; 2) develop and validate methods to calculate regional measures of cortical shape and volume; 3) develop and validate automatic labelling of sulci and gryi; and 4) conduct studies of cortical variability and volume changes in normal aging. All methods will be extensively validated using both computer phantoms and manual in vivo truth models. The methods we develop to automatically represent and label the cortex in large numbers of subjects should also be useful in 1) the development of a description of normal versus diseased cortical geometry, 2) automatic landmark generation for deformable atlas registration, 3) statistical correlation studies of structure/function relationships, and 4) the analysis of morphological changes in ontogenesis, phylogenesis, aging, and disease.
| Shiee, Navid; Bazin, Pierre-Louis; Cuzzocreo, Jennifer L et al. (2014) Reconstruction of the human cerebral cortex robust to white matter lesions: method and validation. Hum Brain Mapp 35:3385-401 |
| Bogovic, John A; Jedynak, Bruno; Rigg, Rachel et al. (2013) Approaching expert results using a hierarchical cerebellum parcellation protocol for multiple inexpert human raters. Neuroimage 64:616-29 |
| Roy, Snehashis; Carass, Aaron; Bazin, Pierre-Louis et al. (2012) Consistent segmentation using a Rician classifier. Med Image Anal 16:524-35 |
| Roy, Snehashis; Carass, Aaron; Prince, Jerry L (2011) COMPRESSED SENSING BASED INTENSITY NON-UNIFORMITY CORRECTION. Proc IEEE Int Symp Biomed Imaging 2011:101-104 |
| Carass, Aaron; Cuzzocreo, Jennifer; Wheeler, M Bryan et al. (2011) Simple paradigm for extra-cerebral tissue removal: algorithm and analysis. Neuroimage 56:1982-92 |
| Chen, Min; Carass, Aaron; Bogovic, John et al. (2011) Distance Transforms in Multi Channel MR Image Registration. Proc SPIE Int Soc Opt Eng 2011: |
| Roy, Snehashis; Carass, Aaron; Shiee, Navid et al. (2010) MR CONTRAST SYNTHESIS FOR LESION SEGMENTATION. Proc IEEE Int Symp Biomed Imaging 2010:932-935 |
| Thambisetty, Madhav; Wan, Jing; Carass, Aaron et al. (2010) Longitudinal changes in cortical thickness associated with normal aging. Neuroimage 52:1215-23 |
| Shiee, Navid; Bazin, Pierre-Louis; Ozturk, Arzu et al. (2010) A topology-preserving approach to the segmentation of brain images with multiple sclerosis lesions. Neuroimage 49:1524-35 |
| Bogovic, John A; Landman, Bennett A; Bazin, Pierre-Louis et al. (2010) Statistical Fusion of Surface Labels Provided by Multiple Raters. Proc SPIE Int Soc Opt Eng 7623: |
Showing the most recent 10 out of 34 publications
