This application will develop magnetic resonance imaging (MRI) criteria to predict outcome of thrombolysis after focal cerebral embolic ischemia in rats. The goal of this proposal is to assess whether the MRI measurements can identify reversibly damaged tissue and identify cerebral tissue that is destined to hemorrhage when treated with a thrombolytic agent. The applicants would also investigate whether the efficacy of thrombolytic intervention can be characterized and predicted by quantitative changes in MRI measurable parameters.
Two specific aims are proposed:
Specific Aim 1 -To predict hemorrhagic transformation (HT) after embolic stroke and thrombolysis in rats using MRI.
Specific Aim 2 a-To identify reversibly damaged ischemic tissue after embolic stroke and thrombolysis in rat using MRI.
Specific Aim 2 b B To determine the ability of MRI to predict the efficacy of thrombolytic intervention with rt-PA. The applicants would employ multimodality MRI and image analysis methodology in combination with histological endpoints to characterize cerebral tissue subjected to embolic stroke and to predict outcome of thrombolytic therapy. The long-term goal is to provide new and important information relevant to the treatment of acute stroke by thrombolysis.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
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Study Section
Special Emphasis Panel (ZRG1-DMG (02))
Program Officer
Jacobs, Tom P
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Henry Ford Health System
Schools of Medicine
United States
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Ding, Guang-Liang; Chopp, Michael; Li, Lian et al. (2014) Magnetic Resonance Imaging of Stroke in the Rat. Bo Pu Xue Za Zhi 31:116-132
Jiang, Quan; Ewing, James R; Chopp, Michael (2012) MRI of blood-brain barrier permeability in cerebral ischemia. Transl Stroke Res 3:56-64
Jiang, Quan; Qu, Changsheng; Chopp, Michael et al. (2011) MRI evaluation of axonal reorganization after bone marrow stromal cell treatment of traumatic brain injury. NMR Biomed 24:1119-28
Li, Lian; Jiang, Quan; Qu, Chang Sheng et al. (2011) Transplantation of marrow stromal cells restores cerebral blood flow and reduces cerebral atrophy in rats with traumatic brain injury: in vivo MRI study. J Neurotrauma 28:535-45
Li, Lian; Jiang, Quan; Ding, Guangliang et al. (2010) Effects of administration route on migration and distribution of neural progenitor cells transplanted into rats with focal cerebral ischemia, an MRI study. J Cereb Blood Flow Metab 30:653-62
Jiang, Quan; Zhang, Zheng Gang; Chopp, Michael (2010) MRI of stroke recovery. Stroke 41:410-4
Chopp, Michael; Steinberg, Gary K; Kondziolka, Douglas et al. (2009) Who's in favor of translational cell therapy for stroke: STEPS forward please? Cell Transplant 18:691-3
Li, Lian; Jiang, Quan; Ding, Guangliang et al. (2009) MRI identification of white matter reorganization enhanced by erythropoietin treatment in a rat model of focal ischemia. Stroke 40:936-41
Athiraman, Hemanthkumar; Jiang, Quan; Ding, Guang Liang et al. (2009) Investigation of relationships between transverse relaxation rate, diffusion coefficient, and labeled cell concentration in ischemic rat brain using MRI. Magn Reson Med 61:587-94
Liu, Xian Shuang; Chopp, Michael; Santra, Manoranjan et al. (2008) Functional response to SDF1 alpha through over-expression of CXCR4 on adult subventricular zone progenitor cells. Brain Res 1226:18-26

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