This is a proposal requesting five years of support for work concerned with the synaptic and functional organization of frontal lobe cortical areas in the control of forelimb movements in primates. In recent years, our concepts about frontal lobe motor areas and corticospinal output organization have changed dramatically. Information about the synaptic connections of single corticospinal cells has shown clearly that these cells typically influence not just one muscle but combinations of muscles as functional muscle synergies. Moreover, the existence of a remarkable number of discrete premotor areas in the frontal lobe of primates has become clear, each with its own complement of corticospinal neurons. In this application we propose to build upon our previous studies concerning the contribution of the cortical motor areas to forelimb movement in primates. This proposal focuses on two major issues. The first builds upon our recent finding that a large fraction (45%) of corticomotoneuronal (CM) cells engaged in a reach and prehension task simultaneously facilitated or suppressed a combination of both proximal and distal muscles in spike triggered averages of EMG activity (McKiernan et al.,1998). These combinations of CM cell target muscles represent multi-joint, functional muscle synergies underlying basic coactivation patterns observed in proximal and distal muscle during reach and prehension movements of the forelimb. A central remaining question concerns the functional importance of the cell's distal and proximal target muscles. Will such cells only be activated for tasks in which the distal and proximal muscles are coactivated as a synergy? The second issue we wish to address concerns the mounting evidence from mostly anatomical studies favoring the existence of multiple, discrete corticospinal representations of limb muscles within the frontal cortex of primates. In addition to a proposed double representation of distal muscles in primary motor cortex, no less than six premotor areas have been suggested based on anatomical labeling of corticospinal neurons and other anatomical studies. These include two premotor areas in the lateral hemisphere, SMA and three areas buried in the cingulate gyrus. Although the presence of substantial corticospinal projections has prompted speculation that these areas represent parallel channels for direct access to motoneurons and movement control, there have been few physiological studies of the efficacy and characteristics of these corticospinal projections in comparison to those from primary motor cortex. The goal of this proposal will be to apply the techniques of spike and stimulus triggered averaging of EMG activity to map and assess the functional nature of these multiple corticospinal forelimb representations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS039023-03
Application #
6394196
Study Section
Special Emphasis Panel (ZRG1-IFCN-1 (03))
Program Officer
Heetderks, William J
Project Start
1999-09-15
Project End
2003-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
3
Fiscal Year
2001
Total Cost
$276,845
Indirect Cost
Name
University of Kansas
Department
Physiology
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
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Boudrias, Marie-Helene; Lee, Sang-Pil; Svojanovsky, Stan et al. (2010) Forelimb muscle representations and output properties of motor areas in the mesial wall of rhesus macaques. Cereb Cortex 20:704-19
Griffin, D M; Hudson, H M; Belhaj-Saif, A et al. (2008) Do corticomotoneuronal cells predict target muscle EMG activity? J Neurophysiol 99:1169-986
Boudrias, Marie-Helene; Belhaj-Saif, Abderraouf; Park, Michael C et al. (2006) Contrasting properties of motor output from the supplementary motor area and primary motor cortex in rhesus macaques. Cereb Cortex 16:632-8
Park, Michael C; Belhaj-Saif, Abderraouf; Cheney, Paul D (2004) Properties of primary motor cortex output to forelimb muscles in rhesus macaques. J Neurophysiol 92:2968-84
Park, M C; Belhaj-Saif, A; Gordon, M et al. (2001) Consistent features in the forelimb representation of primary motor cortex in rhesus macaques. J Neurosci 21:2784-92
Cheney, P D; Hill-Karrer, J; Belhaj-Saif, A et al. (2000) Cortical motor areas and their properties: implications for neuroprosthetics. Prog Brain Res 128:135-60
Park, M C; Belhaj-Saif, A; Cheney, P D (2000) Chronic recording of EMG activity from large numbers of forelimb muscles in awake macaque monkeys. J Neurosci Methods 96:153-60