Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS039060-01
Application #
2898727
Study Section
Special Emphasis Panel (ZRG1-BDCN-3 (01))
Program Officer
Marler, John R
Project Start
1999-09-21
Project End
2002-06-30
Budget Start
1999-09-21
Budget End
2000-06-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Toronto General Hospital
Department
Type
DUNS #
City
Toronto
State
Country
Canada
Zip Code
Aarts, Michelle M; Tymianski, Michael (2004) Molecular mechanisms underlying specificity of excitotoxic signaling in neurons. Curr Mol Med 4:137-47
Arundine, M; Tymianski, M (2004) Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci 61:657-68
Arundine, Mark; Chopra, Gopal K; Wrong, Andrew et al. (2003) Enhanced vulnerability to NMDA toxicity in sublethal traumatic neuronal injury in vitro. J Neurotrauma 20:1377-95
Arundine, Mark; Tymianski, Michael (2003) Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 34:325-37
Aarts, Michelle; Iihara, Koji; Wei, Wen-Li et al. (2003) A key role for TRPM7 channels in anoxic neuronal death. Cell 115:863-77
Aarts, Michelle; Liu, Yitao; Liu, Lidong et al. (2002) Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science 298:846-50
Sattler, R; Tymianski, M (2001) Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol Neurobiol 24:107-29
Iihara, K; Joo, D T; Henderson, J et al. (2001) The influence of glutamate receptor 2 expression on excitotoxicity in Glur2 null mutant mice. J Neurosci 21:2224-39
Sattler, R; Xiong, Z; Lu, W Y et al. (2000) Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity. J Neurosci 20:22-33
Sattler, R; Xiong, Z; Lu, W Y et al. (1999) Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 284:1845-8