Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS039075-03
Application #
6394209
Study Section
Special Emphasis Panel (ZRG1-BDCN-3 (01))
Program Officer
Behar, Toby
Project Start
1999-07-10
Project End
2003-04-30
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
3
Fiscal Year
2001
Total Cost
$308,573
Indirect Cost

  Institution

Name
Henry Ford Health System
Department
Pathology
Type
Schools of Medicine
DUNS #
073134603
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Anagli, John; Han, Yuxia; Stewart, Laura et al. (2009) A novel calpastatin-based inhibitor improves postischemic neurological recovery. Biochem Biophys Res Commun 385:94-9
Anagli, John; Abounit, Kadija; Stemmer, Paul et al. (2008) Effects of cathepsins B and L inhibition on postischemic protein alterations in the brain. Biochem Biophys Res Commun 366:86-91
Betts, Russell; Anagli, John (2004) The beta- and gamma-CH2 of B27-WT's Leu11 and Ile18 side chains play a direct role in calpain inhibition. Biochemistry 43:2596-604
Betts, Russell; Weinsheimer, Shantel; Blouse, Grant E et al. (2003) Structural determinants of the calpain inhibitory activity of calpastatin peptide B27-WT. J Biol Chem 278:7800-9
Seyfried, D M; Veyna, R; Han, Y et al. (2001) A selective cysteine protease inhibitor is non-toxic and cerebroprotective in rats undergoing transient middle cerebral artery ischemia. Brain Res 901:94-101