Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS039267-01
Application #
2840303
Study Section
Special Emphasis Panel (ZRG1-BDCN-3 (02))
Program Officer
Murphy, Diane
Project Start
1999-06-01
Project End
2004-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Children's Memorial Hospital (Chicago)
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60611
Smith, A D; Kozlowski, D A; Bohn, M C et al. (2005) Effect of AdGDNF on dopaminergic neurotransmission in the striatum of 6-OHDA-treated rats. Exp Neurol 193:420-6
Jaumotte, Juliann D; Zigmond, Michael J (2005) Dopaminergic innervation of forebrain by ventral mesencephalon in organotypic slice co-cultures: effects of GDNF. Brain Res Mol Brain Res 134:139-46
Kozlowski, D A; Miljan, E A; Bremer, E G et al. (2004) Quantitative analyses of GFRalpha-1 and GFRalpha-2 mRNAs and tyrosine hydroxylase protein in the nigrostriatal system reveal bilateral compensatory changes following unilateral 6-OHDA lesions in the rat. Brain Res 1016:170-81
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Ugarte, Susana D; Lin, Eva; Klann, Eric et al. (2003) Effects of GDNF on 6-OHDA-induced death in a dopaminergic cell line: modulation by inhibitors of PI3 kinase and MEK. J Neurosci Res 73:105-12
Smith, Amanda D; Antion, Marci; Zigmond, Michael J et al. (2003) Effect of 6-hydroxydopamine on striatal GDNF and nigral GFRalpha1 and RET mRNAs in the adult rat. Brain Res Mol Brain Res 117:129-38
Smith, Amanda D; Zigmond, Michael J (2003) Can the brain be protected through exercise? Lessons from an animal model of parkinsonism. Exp Neurol 184:31-9
Gerin, Christine (2002) Behavioral improvement and dopamine release in a Parkinsonian rat model. Neurosci Lett 330:5-8
Zigmond, Michael J; Hastings, Teresa G; Perez, Ruth G (2002) Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity? Parkinsonism Relat Disord 8:389-93
Connor, B; Kozlowski, D A; Unnerstall, J R et al. (2001) Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects dopaminergic terminals from degeneration. Exp Neurol 169:83-95

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