While advances in Parkinson's disease have been established in recent years, the pathogenesis of the disease is still not well understood. The primary goal of this project is to quantify how complex multijoint movement is impaired in Parkinsonian patients, thereby providing a better understanding of how motor control principles are compromised. Our working hypothesis concerning PD patients is that much of their difficulty with complex movements arises from their inability to coordinate body segments. We use a trunk-assisted prehension task and analyze trunk, arm, and aperture synchronization when speed, accuracy, sequencing of segments, and visual feedback constraints are imposed. We will analyze body segment synchronization, relative timing, spatial invariance, and synergies. Collectively, the results from these experiments will allow us to better understand how PD affects movement coordination patterns during the performance of complex actions. Comparisons of 'off' vs. 'on' states in Parkinson's disease patients may help determine if coordination impairments share a common levodopa basis. The experiments proposed are systematic, novel and use proven methodology. The proposed research should advance understanding of the fundamental principles that guide the coordination of multijoint movements in normal subjects. It will also increase understanding of the ways in which Parkinson's disease patients are restricted in the use of these principles. The results from four experiments should be useful to both the basic neuroscientist and clinical science communities, reducing the gap between fundamental knowledge of neural mechanisms and therapeutic intervention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS039352-02
Application #
6394267
Study Section
Special Emphasis Panel (ZRG1-BBBP-7 (01))
Program Officer
Sheehy, Paul A
Project Start
2000-09-01
Project End
2005-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
2
Fiscal Year
2001
Total Cost
$305,000
Indirect Cost
Name
Arizona State University-Tempe Campus
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
188435911
City
Tempe
State
AZ
Country
United States
Zip Code
85287
Rand, Miya K; Van Gemmert, Arend W A; Hossain, Abul B M I et al. (2014) Coordination deficits during trunk-assisted reach-to-grasp movements in Parkinson's disease. Exp Brain Res 232:61-74
Rand, Miya K; Van Gemmert, Arend W A; Hossain, Abul B M I et al. (2012) Control of aperture closure initiation during trunk-assisted reach-to-grasp movements. Exp Brain Res 219:293-304
Ringenbach, Shannon D R; van Gemmert, Arend W A; Shill, Holly A et al. (2011) Auditory instructional cues benefit unimanual and bimanual drawing in Parkinson's disease patients. Hum Mov Sci 30:770-82
Rand, Miya Kato; Lemay, Martin; Squire, Linda M et al. (2010) Control of aperture closure initiation during reach-to-grasp movements under manipulations of visual feedback and trunk involvement in Parkinson's disease. Exp Brain Res 201:509-25
Park, Jin-Hoon; Stelmach, George E (2009) Integration deficiencies associated with continuous limb movement sequences in Parkinson's disease. Parkinsonism Relat Disord 15:682-7
Rand, Miya K; Shimansky, Y P; Hossain, Abul B M I et al. (2008) Quantitative model of transport-aperture coordination during reach-to-grasp movements. Exp Brain Res 188:263-74
Rand, Miya K; Lemay, Martin; Squire, Linda M et al. (2007) Role of vision in aperture closure control during reach-to-grasp movements. Exp Brain Res 181:447-60
Lee, Gyusung; Fradet, Laetitia; Ketcham, Caroline J et al. (2007) Efficient control of arm movements in advanced age. Exp Brain Res 177:78-94
Park, Jin-Hoon; Stelmach, George E (2007) Force development during target-directed isometric force production in Parkinson's disease. Neurosci Lett 412:173-8
Rand, Miya K; Squire, Linda M; Stelmach, George E (2006) Effect of speed manipulation on the control of aperture closure during reach-to-grasp movements. Exp Brain Res 174:74-85

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