Neurocysticercosis (NC) is endemic in much of the developing world. It is a major cause of neurologic morbidity and is said to be the primary cause of epilepsy. Traditionally considered an exotic disease in the United States, NC is being seen with increasing frequency in the United States. This is related to immigration as well as travel to endemic area. NC accounts for 2 percent of neurologic and neurosurgical admissions in southern California and there are more than 1,000 cases per year in the United States. An outbreak of cysticercosis among orthodox Jews living in New York City was reported after food was contaminated with T. solium eggs by immigrant cooks infected with the pork tapeworm. The Center for Disease Control considers NC an emerging infection, and they are developing programs to track and hopefully eradicate the condition. While a considerable literature exists regarding treatment of NC, for most clinicians, decisions regarding treatment strategies present a serious dilemma. There are few randomized trials of the treatment of NC. These report conflicting results and raise serious questions regarding the efficacy of current treatments and the long-term cost-benefit ratio. None have adequate power to answer even basic questions regarding optimal management. We herein propose a pilot study to develop methods to conduct a multicenter trial to determine of optimal treatment of acute NC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS039403-01
Application #
6031406
Study Section
Special Emphasis Panel (ZNS1-SRB-W (01))
Program Officer
Fureman, Brandy E
Project Start
2000-08-07
Project End
2003-07-31
Budget Start
2000-08-07
Budget End
2001-07-31
Support Year
1
Fiscal Year
2000
Total Cost
$504,435
Indirect Cost
Name
Columbia University (N.Y.)
Department
Neurology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Kelvin, Elizabeth A; Yung, Janette; Fong, Man Wah et al. (2012) The association of living conditions and lifestyle factors with burden of cysts among neurocysticercosis patients in Ecuador. Trans R Soc Trop Med Hyg 106:763-9
Kelvin, Elizabeth A; Carpio, Arturo; Bagiella, Emilia et al. (2011) Seizure in people with newly diagnosed active or transitional neurocysticercosis. Seizure 20:119-25
Kelvin, E A; Carpio, A; Bagiella, E et al. (2009) The association of host age and gender with inflammation around neurocysticercosis cysts. Ann Trop Med Parasitol 103:487-99
Kelvin, Elizabeth A; Carpio, Arturo; Hesdorffer, Dale C et al. (2009) Investigation of familial aggregation of seizures in neurocysticercosis patients. Epilepsy Res 84:67-71
Carpio, A; Kelvin, E A; Bagiella, E et al. (2008) Effects of albendazole treatment on neurocysticercosis: a randomised controlled trial. J Neurol Neurosurg Psychiatry 79:1050-5
Carpio, Arturo; Hauser, W Allen (2002) Prognosis for seizure recurrence in patients with newly diagnosed neurocysticercosis. Neurology 59:1730-4