Pain-related disorders present a significant economic and clinical problem. The development of treatments is hindered by a lack of information regarding the basic brain mechanisms that support sensory aspects of pain experience. Functional imaging studies provide powerful tools for addressing this issue in human subjects. The investigators have identified activity within a highly distributed network of brain regions that may contribute to sensory-discriminative pain processes. The relationship of this activation to awareness of specific features of pain such as intensity and location, however, remains poorly understood. These perceived sensory aspects of pain can be modulated by cognitive interpretation and expectations about the nature of the stimulus. The brain mechanisms underlying this modulation remain unknown. We propose a series of psychophysical and functional imaging studies to test the hypotheses that 1) parieto-frontal mechanisms are engaged during awareness of the location and intensity of painful stimuli; and 2) that activation within these areas can be modulated by cognitive processes related to expectations about the nature of painful stimuli. These studies will enhance our knowledge of brain mechanisms underlying the pain experience and will provide new directions for the behavioral management of pain.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS039426-02
Application #
6477152
Study Section
Special Emphasis Panel (ZRG1-IFCN-5 (04))
Program Officer
Edwards, Emmeline
Project Start
2000-12-22
Project End
2004-11-30
Budget Start
2001-12-01
Budget End
2002-11-30
Support Year
2
Fiscal Year
2002
Total Cost
$340,797
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Quevedo, Alexandre S; Mørch, Carsten Dahl; Andersen, Ole K et al. (2017) Lateral inhibition during nociceptive processing. Pain 158:1046-1052
Mørch, Carsten Dahl; Frahm, Ken Steffen; Coghill, Robert C et al. (2015) Distinct temporal filtering mechanisms are engaged during dynamic increases and decreases of noxious stimulus intensity. Pain 156:1906-12
Zeidan, Fadel; Lobanov, Oleg V; Kraft, Robert A et al. (2015) Brain mechanisms supporting violated expectations of pain. Pain 156:1772-85
Emerson, Nichole M; Zeidan, Fadel; Lobanov, Oleg V et al. (2014) Pain sensitivity is inversely related to regional grey matter density in the brain. Pain 155:566-73
Nahman-Averbuch, Hadas; Martucci, Katherine T; Granovsky, Yelena et al. (2014) Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information. Pain 155:2491-501
Lobanov, Oleg V; Zeidan, Fadel; McHaffie, John G et al. (2014) From cue to meaning: brain mechanisms supporting the construction of expectations of pain. Pain 155:129-36
Lobanov, Oleg V; Quevedo, Alexandre S; Hadsel, Morten S et al. (2013) Frontoparietal mechanisms supporting attention to location and intensity of painful stimuli. Pain 154:1758-68
Zeidan, Fadel; Coghill, Robert C (2013) Functional connections between self-referential thought and chronic pain: a dysfunctional relationship. Pain 154:3-4
Zeidan, F; Grant, J A; Brown, C A et al. (2012) Mindfulness meditation-related pain relief: evidence for unique brain mechanisms in the regulation of pain. Neurosci Lett 520:165-73
Laurienti, Paul J; Joyce, Karen E; Telesford, Qawi K et al. (2011) Universal fractal scaling of self-organized networks. Physica A 390:3608-3613

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