Amyotrophic lateral sclerosis (ALS) is a progressive, uniformly lethal neurodegenerative disorder. Recent genetic and biochemical studies implicate glutamate excitotoxicity, free radical toxicity, and mitochondrial dysfunction as possible causes of familial ALS and sporadic ALS. This study will test the hypothesis that glutamate excitotoxicity plays a role in the pathogenesis of ALS. If this hypothesis is correct, pharmacological agents that block glutamate receptors may be therapeutic in ALS. The proposed study will determine whether therapeutic intervention with the topiramate, a glutamate receptor blocking agent, will slow the progressive deterioration of motor function in subjects with ALS. Topiramate is a FDA approved agent for epilepsy. Topiramate has modulatory effects on glutamate neurotransmission by blocking kainate/alpha-amino-3-hydroxy-5- methyl-4-isoxazole-propionic acid (AMPA) excitatory receptors. Topiramate protected motor neurons in an in vitro model of chronic glutamate toxicity in a dose dependent fashion. The applicant will conduct a double-blind, randomized, placebo- controlled, study of the safety and efficacy of Topiramate therapy in slowing of disease progression in 288 patients with ALS. All patients will be recruited from the Massachusetts General Hospital and 15 other clinical sites. The primary outcome measure is change in upper extremity motor function after twelve months of experimental therapy as tested with quantitative neuromuscular examination. Secondary outcome measures include grip strength, forced vital capacity, the ALS functional rating scale, and the safety and tolerability of topiramate in this population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS039988-01
Application #
6089101
Study Section
Special Emphasis Panel (ZNS1-SRB-W (01))
Program Officer
Heemskerk, Jill E
Project Start
2000-07-29
Project End
2003-06-30
Budget Start
2000-07-29
Budget End
2001-06-30
Support Year
1
Fiscal Year
2000
Total Cost
$390,077
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Cudkowicz, M E; Shefner, J M; Schoenfeld, D A et al. (2003) A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis. Neurology 61:456-64