One of the most debilitating aspects of Parkinson?s disease is the inability to initiate and execute movements as intended. The fundamental hypothesis behind the proposed research is that basal ganglia impairments, as reflected in Parkinson?s disease, causes a disruption in motor programming processes. It is postulated that there is increased noise in the basal ganglia that produce abnormal timing, patterning, and synchronization of discharges into the motor cortical areas. These irregularities in turn reduce motor programming capabilities that are reflected as alterations in the microstructure of a goal-oriented movement. We have documented that Parkinson?s patients produce movements that exhibit shortened primary submovement components, which then requires secondary, corrective movements. Seven experiments are proposed which examine whether the altered substructure of movements observed in PD is related to muscle activation patterns, force-force variability relationships, and/or a reduced capability to incorporate proprioceptive information at different stages of movement planning and execution. The results of these experiments will be evaluated in combination to allow us to determine which of these potential causes has the greatest impact on primary submovement distance. The data obtained will be useful in the basic science realm as well as the clinical setting; the former by isolating the various motor deficits associated with PD, which may allow for inferences to be made regarding structure-function relationships. In terms of clinical relevance these results will assist in identifying where practitioner interventions or outcome measures should be targeted.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS040266-05
Application #
7025781
Study Section
Nursing Research Study Section (NURS)
Program Officer
Sieber, Beth-Anne
Project Start
2002-03-15
Project End
2010-02-28
Budget Start
2006-03-01
Budget End
2010-02-28
Support Year
5
Fiscal Year
2006
Total Cost
$278,303
Indirect Cost
Name
Arizona State University-Tempe Campus
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
943360412
City
Tempe
State
AZ
Country
United States
Zip Code
85287
Rand, Miya K; Van Gemmert, Arend W A; Hossain, Abul B M I et al. (2014) Coordination deficits during trunk-assisted reach-to-grasp movements in Parkinson's disease. Exp Brain Res 232:61-74
Poston, Brach; Van Gemmert, Arend W A; Sharma, Siddharth et al. (2013) Movement trajectory smoothness is not associated with the endpoint accuracy of rapid multi-joint arm movements in young and older adults. Acta Psychol (Amst) 143:157-67
Rand, Miya K; Van Gemmert, Arend W A; Hossain, Abul B M I et al. (2012) Control of aperture closure initiation during trunk-assisted reach-to-grasp movements. Exp Brain Res 219:293-304
Ringenbach, Shannon D R; van Gemmert, Arend W A; Shill, Holly A et al. (2011) Auditory instructional cues benefit unimanual and bimanual drawing in Parkinson's disease patients. Hum Mov Sci 30:770-82
Rand, Miya Kato; Lemay, Martin; Squire, Linda M et al. (2010) Control of aperture closure initiation during reach-to-grasp movements under manipulations of visual feedback and trunk involvement in Parkinson's disease. Exp Brain Res 201:509-25
Broderick, Michael P; Van Gemmert, Arend W A; Shill, Holly A et al. (2009) Hypometria and bradykinesia during drawing movements in individuals with Parkinson's disease. Exp Brain Res 197:223-33
Park, Jin-Hoon; Stelmach, George E (2009) Integration deficiencies associated with continuous limb movement sequences in Parkinson's disease. Parkinsonism Relat Disord 15:682-7
Poston, Brach; Van Gemmert, Arend W A; Barduson, Beth et al. (2009) Movement structure in young and elderly adults during goal-directed movements of the left and right arm. Brain Cogn 69:30-8
Rand, Miya K; Shimansky, Y P; Hossain, Abul B M I et al. (2008) Quantitative model of transport-aperture coordination during reach-to-grasp movements. Exp Brain Res 188:263-74
Rand, Miya K; Lemay, Martin; Squire, Linda M et al. (2007) Role of vision in aperture closure control during reach-to-grasp movements. Exp Brain Res 181:447-60

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