The goal of this technology development program is to create a resource for fabrication and development of multichannel voltage and chemical sensor systems for the Neurosciences.
The aim i s to address the need to take advantage of new microcircuit fabrication techniques that have been recently developed within the Center for High Density Electronics at the U. Arkansas under direction of Dr. S. Ang. The plan is to work on four major aims in parallel.
The first aim i s to fabricate a new generation of small silicon-based multisite microprobes with sites specialized for either or both voltage or electrochemical sensing. Evaluation and study of sensor site properties will be conducted by Drs. I Fritsch (U. Ark.), D. Woodward (Wake Forest U.), and R.M. Wightman (U.N. Carolina).
A second aim i s to integrate the silicon probe into flexible polyimide cable system. New technologies for fabrication and coating of such materials will be adapted for in vivo Neuroscience applications.
A third aim i s to design and fabricate multichannel VLSI microchip headstage devices to amplify and transmit information from the voltage and electrochemcal sensor sites. The chip design will include the capacity to microstimulate through the voltage sensor sites or to apply polarization voltages at the electrochemical sites. Prototype designs already in progress will be developed further. The VLSI microcircuit will be integrated into the probe design to achieve higher desensity integration. A multiple probe configuration will be developed as the basic module is perfected. A wireless transmission system with an integrated DSP will be developed to digitize and transmit multichannel information at high rates to a host computer. A dual processor host PC workstation with the Windows NT Operating System will be further developed with software enhancements to manage the multichannel data flow and analysis. Education of students and training of users will be continued and expanded. As has been done previously, interactions with small businesses will be developed to disseminate utility of the technology development. This project will provide technology critical for ongoing research and therapeutic needs in Neuroscience of many NIH Institutes, including NIDA, NIA, NIAAA, NINDS, and NIMH.
|Wang, Jin-Yan; Zhang, Han-Ti; Chang, Jing-Yu et al. (2008) Anticipation of pain enhances the nociceptive transmission and functional connectivity within pain network in rats. Mol Pain 4:34|
|Chang, Jing-Yu; Shi, Li-Hong; Luo, Fei et al. (2008) Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease. Neurosci Biobehav Rev 32:352-66|
|Wang, Jin-Yan; Chang, Jing-Yu; Woodward, Donald J et al. (2008) Temporal strategy for discriminating noxious from non-noxious electrical stimuli by cortical and thalamic neural ensembles in rats. Neurosci Lett 435:163-8|
|Shi, Li-Hong; Luo, Fei; Woodward, Donald J et al. (2007) Temporal sequence of ictal discharges propagation in the corticolimbic basal ganglia system during amygdala kindled seizures in freely moving rats. Epilepsy Res 73:85-97|
|Wang, Jin-Yan; Chang, Jing-Yu; Woodward, Donald J et al. (2007) Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats. Synapse 61:335-42|
|Chang, Jing-Yu; Shi, Li-Hong; Luo, Fei et al. (2007) Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease. Neurosci Biobehav Rev 31:643-57|
|Shi, Li-Hong; Luo, Fei; Woodward, Donald et al. (2006) Deep brain stimulation of the substantia nigra pars reticulata exerts long lasting suppression of amygdala-kindled seizures. Brain Res 1090:202-7|
|Etienne, Mathieu; Anderson, Emily C; Evans, Stephanie R et al. (2006) Feedback-independent Pt nanoelectrodes for shear force-based constant-distance mode scanning electrochemical microscopy. Anal Chem 78:7317-24|
|Shi, Li-Hong; Luo, Fei; Woodward, Donald J et al. (2006) Basal ganglia neural responses during behaviorally effective deep brain stimulation of the subthalamic nucleus in rats performing a treadmill locomotion test. Synapse 59:445-57|
|Shi, Li-Hong; Woodward, Donald J; Luo, Fei et al. (2004) High-frequency stimulation of the subthalamic nucleus reverses limb-use asymmetry in rats with unilateral 6-hydroxydopamine lesions. Brain Res 1013:98-106|
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