The broad, long-term objective of this application is to develop intermolecular double-quantum coherence (iDQC) MR imaging with particular focus on applications in the brain. This is based on the primary hypothesis that iDQC provides novel and unique imaging contrast which is relevant to and potentially useful in a wide variety of important MRI applications, including brain fMRI, detection of hypoxia in tumors, diffusion-weighted imaging, and characterization of trabecular bones. However, owing to the early nature of the technique, we believe that it is crucial to gain a better understanding of fundamentals of iDQC imaging contrast mechanisms, and to determine the key factors for imaging optimization before applications of iDQC imaging become practical.
The specific aims of this proposal are therefore to quantify the novel iDQC image contrast in terms of intrinsic parameters (including relaxation, diffusion, sensitivity to magnetic susceptibility distributions, and dependence of iDQC signals on microstructures) and experimental parameters (field strength, pulse timing, coherence selection, detection method).
These aims are achieved via research designs and methods in development of optimal iDQC imaging techniques with high SNR and unique contrast characteristics, guided by theoretical analyses and computer simulations, and validated with measurements in phantoms and rat brains at 1.5 9.4 and 14T, and brains of normal human volunteers at 1.5T. Our pulse sequence optimization will be approached from signal excitation, signal detection, and image post-processing, based on the unique characteristics of iDQC signals. The outcome of this study should lead to quantitation of essential factors for iDQC imaging contrast, and much improved imaging techniques applicable for a variety of novel applications at different field strengths.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS041048-02
Application #
6623708
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Chen, Daofen
Project Start
2002-04-01
Project End
2005-03-30
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
2
Fiscal Year
2003
Total Cost
$262,378
Indirect Cost
Name
University of Rochester
Department
Radiation-Diagnostic/Oncology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Lin, Yanqin; Chen, Zhong; Zhong, Jianhui (2011) Signal-to-noise ratio enhancement of intermolecular double-quantum coherence MR spectroscopy in inhomogeneous fields with phased array coils on a 3 Tesla whole-body scanner. J Magn Reson Imaging 33:698-703
Lin, Yanqin; Gu, Tianliang; Chen, Zhong et al. (2010) High-resolution MRS in the presence of field inhomogeneity via intermolecular double-quantum coherences on a 3-T whole-body scanner. Magn Reson Med 63:303-11
Chen, Zhong; Cai, Shuhui; Chen, Zhiwei et al. (2009) Fast acquisition of high-resolution NMR spectra in inhomogeneous fields via intermolecular double-quantum coherences. J Chem Phys 130:084504
Chen, Xi; Lin, Meijin; Chen, Zhong et al. (2009) Fast acquisition scheme for achieving high-resolution MRS with J-scaling under inhomogeneous fields. Magn Reson Med 61:775-84
Lin, Yanqin; Chen, Zhong; Cai, Shuhui et al. (2008) Accurate measurements of small J coupling constants under inhomogeneous fields via intermolecular multiple-quantum coherences. J Magn Reson 190:298-306
Zhang, Shengchun; Zhu, Xiaoqin; Chen, Zhong et al. (2008) Improvement in the contrast of CEST MRI via intermolecular double quantum coherences. Phys Med Biol 53:N287-96
Gu, T; Kennedy, S D; Chen, Z et al. (2007) Functional MRI at 3T using intermolecular double-quantum coherence (iDQC) with spin-echo (SE) acquisitions. MAGMA 20:255-64
Wong, Chung Ki; Kennedy, Scott D; Kwok, Edmund et al. (2007) Theoretical studies of the effect of the dipolar field in multiple spin-echo sequences with refocusing pulses of finite duration. J Magn Reson 185:247-58
Lin, Tao; Sun, Huijun; Chen, Zhong et al. (2007) Numerical simulations of motion-insensitive diffusion imaging based on the distant dipolar field effects. Magn Reson Imaging 25:1409-16
Chen, Xi; Lin, Meijin; Chen, Zhong et al. (2007) High-resolution intermolecular zero-quantum coherence spectroscopy under inhomogeneous fields with effective solvent suppression. Phys Chem Chem Phys 9:6231-40

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