Mechanisms of Regulation of Autoimmune Th1 CD4 T cells

Dalton, Dyana K.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Project (R01)
• Project #: 5R01NS043355-02
• Application #: 6688933
• Study Section: Immunological Sciences Study Section (IMS)
• Program Officer: Utz, Ursula
• Project Start: 2002-12-15
• Project End: 2007-11-30
• Budget Start: 2003-12-01
• Budget End: 2004-11-30
• Support Year: 2
• Fiscal Year: 2004
• Total Cost: $328,700

Institution

• Name: Trudeau Institute, Inc.
• DUNS #: 020658969
• City: Saranac Lake
• State: NY
• Country: United States
• Zip Code: 12983

Publications

O'Connor, Richard A; Li, Xujian; Blumerman, Seth et al. (2012) Adjuvant immunotherapy of experimental autoimmune encephalomyelitis: immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3+CXCR6+ and myelin-specific T cells to the draining lymph nodes rather than the central nervous system. J Immunol 188:2093-101

Li, Xujian; McKinstry, K Kai; Swain, Susan L et al. (2007) IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. J Immunol 179:939-49

Dalton, Dyana K; Wittmer, Susan (2005) Nitric-oxide-dependent and independent mechanisms of protection from CNS inflammation during Th1-mediated autoimmunity: evidence from EAE in iNOS KO mice. J Neuroimmunol 160:110-21

O'Connor, Richard A; Wittmer, Susan; Dalton, Dyana K (2005) Infection-induced apoptosis deletes bystander CD4+ T cells: a mechanism for suppression of autoimmunity during BCG infection. J Autoimmun 24:93-100