The goals of Gene Expression in Inflammatory Myopathies are: (1) to characterize patterns of muscle gene expression through the use of DNA microarrays among adult patients with distinct subtypes of inflammatory myopathies and correlate these patterns with clinical phenotypes, and (2) to formulate hypotheses relevant to the pathogenesis of the inflammatory myopathies. High-density oligonucleotide microarrays will be used to assay gene expression in muscle biopsy specimens from patients with inflammatory myopathies. These patients will be phenotypically well described and known to the clinical investigators of this proposal. Data analysis of gene expression profiles will be linked to clinical data to refine disease classification and understand distinctions among and within the major subtypes of inflammatory myopathy. Analysis of differential gene expression will also provide clues to pathogenesis of these disorders. This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis.
| Greenberg, Steven A (2010) Theories of the pathogenesis of inclusion body myositis. Curr Rheumatol Rep 12:221-8 |
| Salajegheh, Mohammad; Kong, Sek Won; Pinkus, Jack L et al. (2010) Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy. Ann Neurol 67:53-63 |
| Greenberg, Steven A (2010) Dermatomyositis and type 1 interferons. Curr Rheumatol Rep 12:198-203 |
| Greenberg, Steven A (2010) Type 1 interferons and myositis. Arthritis Res Ther 12 Suppl 1:S4 |
| Salajegheh, Mohammad; Pinkus, Jack L; Amato, Anthony A et al. (2010) Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles. Muscle Nerve 42:576-83 |
| Greenberg, Steven A (2009) How citation distortions create unfounded authority: analysis of a citation network. BMJ 339:b2680 |
| Salajegheh, Mohammad; Pinkus, Jack L; Taylor, J Paul et al. (2009) Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis. Muscle Nerve 40:19-31 |
| Greenberg, Steven A (2009) Inflammatory myopathies: disease mechanisms. Curr Opin Neurol 22:516-23 |
| Salajegheh, Mohammad; Pinkus, Jack L; Nazareno, Remedios et al. (2009) Nature of ""Tau"" immunoreactivity in normal myonuclei and inclusion body myositis. Muscle Nerve 40:520-8 |
| Parker, Kenneth C; Kong, Sek Won; Walsh, Ronan J et al. (2009) Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis. Muscle Nerve 39:739-53 |
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