? The limitations of radiographic visualization and the lack of consideration of the influence of stentt deployment on details of blood flow have limited stentt design to forms which are uniform and circularly symmetric. Yet some of the most important potential applications of stents such as in the treatment of aneurysms are inherently non-uniform and non-symmetric in nature. In this project, the design of innovative asymmetric stents and their deployment enabled by guidance with new high resolution x-ray image detectors are investigated. In particular, the limitations and accuracy in localizing the rotational orientation as well as the longitudinal distance of small asymmetric devices delivered by catheters within the vasculature under radiographic guidance are explored for the first time. This new capability for accurate localization will allow the implementation of new devices such as asymmetric, variable porosity stentts for treatment of cerebral aneurysms by modifying aneurysm blood flow characteristics. To optimize the new stentt design, flow reduction in aneurysms needed to induce thrombosis will be explored. Also details of flow and flow modification will be investigated using advanced theoretical and experimental methods. It is expected that this new capability should enable more rapid treatment of aneurysms with less chance of hemorrhage and decreased possibility for recurrence compared with existing procedures and additionally readily enable treatment of wide-necked and giant cerebral aneurysms for the first time. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS043924-02
Application #
6884048
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Golanov, Eugene V
Project Start
2004-04-15
Project End
2008-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
2
Fiscal Year
2005
Total Cost
$635,625
Indirect Cost
Name
State University of New York at Buffalo
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Kan, Peter; Yashar, Parham; Ionita, Ciprian N et al. (2013) Endovascular coil embolization of a very small ruptured aneurysm using a novel microangiographic technique: technical note. J Neurointerv Surg 5:e2
Binning, M J; Yashar, P; Orion, D et al. (2012) Use of the Outreach Distal Access Catheter for microcatheter stabilization during intracranial arteriovenous malformation embolization. AJNR Am J Neuroradiol 33:E117-9
Ionita, C N; Natarajan, S K; Wang, W et al. (2011) Evaluation of a second-generation self-expanding variable-porosity flow diverter in a rabbit elastase aneurysm model. AJNR Am J Neuroradiol 32:1399-407
Suri, H; Ionita, C N; Baier, R E et al. (2011) New variable porosity flow diverter (VPOD) stent design for treatment of cerebrovascular aneurysms. Conf Proc IEEE Eng Med Biol Soc 2011:1105-8
Binning, Mandy J; Orion, David; Yashar, Parham et al. (2011) Use of the microangiographic fluoroscope for coiling of intracranial aneurysms. Neurosurgery 69:1131-8
Ionita, Ciprian N; Suri, Himanshu; Nataranjian, Sabareesh et al. (2011) Angiographic imaging evaluation of patient-specific bifurcation-aneurysm phantom treatment with pre-shaped, self-expanding, flow-diverting stents: feasibility study. Proc SPIE Int Soc Opt Eng 7965:79651H1-79651H9
Panse, Ashish; Ionita, C N; Wang, W et al. (2010) The Micro-Angiographic Fluoroscope (MAF) in High Definition (HD) Mode for Improved Contrast-to-Noise Ratio and Resolution in Fluoroscopy and Roadmapping. IEEE Nucl Sci Symp Conf Rec (1997) :3217-3220
Ionita, Ciprian N; Wang, Weiyuan; Bednarek, Daniel R et al. (2010) Assessment of contrast flow modification in aneurysms treated with closed-cell self-deploying asymmetric vascular stents (SAVS). Proc SPIE Int Soc Opt Eng 7626:
Patel, V; Chityala, R N; Hoffmann, K R et al. (2009) Self-calibration of a cone-beam micro-CT system. Med Phys 36:48-58
Ionita, Ciprian N; Paciorek, Ann M; Dohatcu, Andreea et al. (2009) The asymmetric vascular stent: efficacy in a rabbit aneurysm model. Stroke 40:959-65

Showing the most recent 10 out of 37 publications