Management of acute, life-threatening neurologic illnesses, such as severe traumatic brain injury, is facilitated by accurate and continuous monitoring of cerebral oxygenation. However, current monitoring systems are invasive, requiring either cannulation of the internal jugular venous bulb or insertion of a probe directly into the brain. Nearinfrared spectroscopy, a noninvasive method of monitoring cerebral blood oxygenation, is promising, but has yet to be satisfactorily calibrated to provide quantitative measurement in adults. At present there is no system for accurate, noninvasive, and continuous monitoring of cerebral blood oxygenation. We proposed and performed in vitro and in vivo testing of a novel optoacoustic technique that accurately and continuously measures blood oxygenation directly from the superior sagittal sinus, a structure that can easily be localized due to the high resolution of the optoacoustic technique. The optoacoustic technique is based on generation of ultrasonic (optoacoustic) waves by laser pulses and detection of these waves by a sensitive acoustic transducer. Optoacoustic monitoring of blood oxygenation utilizes well-established differences in the optical absorption coefficients of oxy- and deoxyhemoglobin in the nearinfrared spectral range. During our current NIH R21 project supported by an NINDS grant under the Program Announcement PA-98-050 (directed at the development of innovative technologies including photoacoustic brain monitoring), we designed, built, and tested a noninvasive optoacoustic system for accurate monitoring of cerebral blood oxygenation. Our in vitro and in vivo (in sheep) studies demonstrated that: (1) the parameters of the optoacoustic waves are linearly dependent on blood oxygenation; (2) the use of specially designed transducers and optoacoustic probes allows sensitive detection despite optical and acoustic attenuation by thick bone; and (3) this technique can measure blood oxygenation with high accuracy. In this grant application, we propose to further develop this technique under this program announcement.
The specific aims of the project are: (1) to modify the optoacoustic system to provide multiwavelength measurements and perform evaluation of the system in cadavers; (2) to evaluate it in vivo in volunteers; and (3) to evaluate the system performance in patients with traumatic brain injury. By the end of the project the system will be developed sufficiently to permit multi-center clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS044345-01A1
Application #
6680586
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Pancrazio, Joseph J
Project Start
2003-06-01
Project End
2006-05-31
Budget Start
2003-06-01
Budget End
2004-05-31
Support Year
1
Fiscal Year
2003
Total Cost
$322,763
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
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Esenaliev, Rinat O (2017) Optoacoustic diagnostic modality: from idea to clinical studies with highly compact laser diode-based systems. J Biomed Opt 22:91512
Petrov, I Y; Petrov, Y; Prough, D S et al. (2012) Optoacoustic monitoring of cerebral venous blood oxygenation though intact scalp in large animals. Opt Express 20:4159-67
Petrova, I Y; Petrov, Y Y; Esenaliev, R O et al. (2009) Noninvasive monitoring of cerebral blood oxygenation in ovine superior sagittal sinus with novel multi-wavelength optoacoustic system. Opt Express 17:7285-94
Patrikeev, Igor; Petrov, Yuriy Y; Petrova, Irina Y et al. (2007) Monte Carlo modeling of optoacoustic signals from human internal jugular veins. Appl Opt 46:4820-7
National Institute of Biomedical Imaging and Bioengineering/National Heart, Lung, and Blood Institute/National Science Foundation Workshop Faculty; Price, Christopher P; Kricka, Larry J (2007) Improving healthcare accessibility through point-of-care technologies. Clin Chem 53:1665-75
Petrov, Yuriy Y; Petrova, Irina Y; Patrikeev, Igor A et al. (2006) Multiwavelength optoacoustic system for noninvasive monitoring of cerebral venous oxygenation: a pilot clinical test in the internal jugular vein. Opt Lett 31:1827-9