Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS045150-02
Application #
6689976
Study Section
Special Emphasis Panel (ZRG1-BDCN-3 (01))
Program Officer
Murphy, Diane
Project Start
2002-12-15
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$388,313
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Savonenko, Alena V; Melnikova, Tatiana; Hiatt, Andrew et al. (2012) Alzheimer's therapeutics: translation of preclinical science to clinical drug development. Neuropsychopharmacology 37:261-77
Chiang, Po-Min; Fortna, Ryan R; Price, Donald L et al. (2012) Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin. Neurobiol Aging 33:277-85
Li, Tong; Li, Yue-Ming; Ahn, Kwangwook et al. (2011) Increased expression of PS1 is sufficient to elevate the level and activity of ?-secretase in vivo. PLoS One 6:e28179
Pardossi-Piquard, Raphaëlle; Yang, Seung-Pil; Kanemoto, Soshi et al. (2009) APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes. J Biol Chem 284:16298-307
Cheng, Haipeng; Vetrivel, Kulandaivelu S; Drisdel, Renaldo C et al. (2009) S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem 284:1373-84
Li, Tong; Wen, Hongjin; Brayton, Cory et al. (2007) Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci 27:10849-59
Li, Tong; Wen, Hongjin; Brayton, Cory et al. (2007) Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem 282:32264-73
Ma, Guojun; Li, Tong; Price, Donald L et al. (2005) APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J Neurosci 25:192-8
Lazarov, Orly; Morfini, Gerardo A; Lee, Edward B et al. (2005) Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci 25:2386-95
Laird, Fiona M; Cai, Huaibin; Savonenko, Alena V et al. (2005) BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci 25:11693-709

Showing the most recent 10 out of 12 publications