Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS045169-02
Application #
6685285
Study Section
Special Emphasis Panel (ZRG1-BDCN-3 (01))
Program Officer
Oliver, Eugene J
Project Start
2002-12-01
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$342,872
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Pharmacology
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Liu, Juan; Yang, Andrew R; Kelly, Timothy et al. (2011) Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala. Proc Natl Acad Sci U S A 108:4465-70
Laing, Jennifer M; Smith, Cynthia C; Aurelian, Laure (2010) Multi-targeted neuroprotection by the HSV-2 gene ICP10PK includes robust bystander activity through PI3-K/Akt and/or MEK/ERK-dependent neuronal release of vascular endothelial growth factor and fractalkine. J Neurochem 112:662-76
Wales, S Q; Laing, J M; Chen, L et al. (2008) ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+. Gene Ther 15:1397-409
Laing, Jennifer M; Golembewski, Erin K; Wales, Samantha Q et al. (2008) Growth-compromised HSV-2 vector Delta RR protects from N-methyl-D-aspartate-induced neuronal degeneration through redundant activation of the MEK/ERK and PI3-K/Akt survival pathways, either one of which overrides apoptotic cascades. J Neurosci Res 86:378-91
Wales, Samantha Q; Li, Baiquan; Laing, Jennifer M et al. (2007) The herpes simplex virus type 2 gene ICP10PK protects from apoptosis caused by nerve growth factor deprivation through inhibition of caspase-3 activation and XIAP up-regulation. J Neurochem 103:365-79
Golembewski, Erin K; Wales, Samantha Q; Aurelian, Laure et al. (2007) The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity. Exp Neurol 203:381-93
Laing, Jennifer M; Gober, Michael D; Golembewski, Erin K et al. (2006) Intranasal administration of the growth-compromised HSV-2 vector DeltaRR prevents kainate-induced seizures and neuronal loss in rats and mice. Mol Ther 13:870-81
Gober, Michael D; Laing, Jennifer M; Thompson, Scott M et al. (2006) The growth compromised HSV-2 mutant DeltaRR prevents kainic acid-induced apoptosis and loss of function in organotypic hippocampal cultures. Brain Res 1119:26-39
Aurelian, L (2005) HSV-induced apoptosis in herpes encephalitis. Curr Top Microbiol Immunol 289:79-111
Aurelian, Laure (2005) Cross talk of signaling and apoptotic cascades in the CNS: target for virus modulation. Front Biosci 10:2776-87

Showing the most recent 10 out of 12 publications