Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS045316-02
Application #
6685280
Study Section
Special Emphasis Panel (ZRG1-BDCN-2 (01))
Program Officer
Oliver, Eugene J
Project Start
2003-01-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$344,375
Indirect Cost
Name
Rush University Medical Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
068610245
City
Chicago
State
IL
Country
United States
Zip Code
60612
Ling, Zaodung; Zhu, Yuangui; Tong, Chong Wai et al. (2009) Prenatal lipopolysaccharide does not accelerate progressive dopamine neuron loss in the rat as a result of normal aging. Exp Neurol 216:312-20
Desai, Brinda S; Monahan, Angela J; Carvey, Paul M et al. (2007) Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy. Cell Transplant 16:285-99
Zhu, Yuangui; Carvey, Paul M; Ling, Zaodung (2007) Altered glutathione homeostasis in animals prenatally exposed to lipopolysaccharide. Neurochem Int 50:671-80
Zhao, Chaohui; Ling, Zaodung; Newman, Mary B et al. (2007) TNF-alpha knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice. Neurobiol Dis 26:36-46
Carvey, Paul M; Punati, Ashok; Newman, Mary B (2006) Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis. Cell Transplant 15:239-50
Zhu, Yuangui; Carvey, Paul M; Ling, Zaodung (2006) Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Res 1090:35-44
Ling, Zaodung; Zhu, Yuangui; Tong, Chong wai et al. (2006) Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally. Exp Neurol 199:499-512
Carvey, P M; Zhao, C H; Hendey, B et al. (2005) 6-Hydroxydopamine-induced alterations in blood-brain barrier permeability. Eur J Neurosci 22:1158-68
Collier, Timothy J; Dung Ling, Zao; Carvey, Paul M et al. (2005) Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism. Exp Neurol 191 Suppl 1:S60-7
Ling, Zaodung; Chang, Qin A; Tong, Chong Wai et al. (2004) Rotenone potentiates dopamine neuron loss in animals exposed to lipopolysaccharide prenatally. Exp Neurol 190:373-83

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