Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS047578-05
Application #
7751828
Study Section
Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section (HAI)
Program Officer
Utz, Ursula
Project Start
2006-01-01
Project End
2011-08-31
Budget Start
2010-01-01
Budget End
2011-08-31
Support Year
5
Fiscal Year
2010
Total Cost
$256,953
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Russi, Abigail E; Brown, Melissa A (2015) The meninges: new therapeutic targets for multiple sclerosis. Transl Res 165:255-69
Christy, Alison L; Walker, Margaret E; Hessner, Martin J et al. (2013) Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE. J Autoimmun 42:50-61
Wong, Larry Y; Hatfield, Julianne K; Brown, Melissa A (2013) Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development. J Biol Chem 288:35170-9
Walker, Margaret E; Hatfield, Julianne K; Brown, Melissa A (2012) New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action? Biochim Biophys Acta 1822:57-65
Sayed, Blayne A; Walker, Margaret E; Brown, Melissa A (2011) Cutting edge: mast cells regulate disease severity in a relapsing-remitting model of multiple sclerosis. J Immunol 186:3294-8
Sayed, Blayne A; Christy, Alison L; Walker, Margaret E et al. (2010) Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment? J Immunol 184:6891-900