Spinal cord injury (SCI) heightens risk for adverse health outcomes and secondary conditions, including poor general health, the development of chronic health conditions such as pain and fatigue, and poor Dsychosocial adaptation including an elevated risk for depression. Although there are substantial individual differences in likelihood of developing these conditions, the risk factors that account for the variations are not fully understood, nor have they been systematically investigated. The purpose of the proposed 10-year longitudinal study is to identify differential risk for 3 sets of adverse health outcomes using two empirical models to guide selection of risk variables. The first general risk model highlights conceptual categories of risk variables from multiple levels including behavioral, psycho-social/environmental, and biographic/injury factors in predicting morbidity and mortality. The second bi-dimensional behavioral model assesses the risk of poor health outcomes along independent risk and protective behavioral dimensions. Preliminary data was collected 10 years prior to collection of the proposed follow-up outcome data from 1,391 adult participants with traumatic SCI of at least 1-year duration. These participants will complete a self-report battery of measures as will a new sample of over 1,000 cases. Measures will include reassessment of risk factors and a detailed assessment of health outcomes. General linear model will be used to explore the cross-sectional data as a prelude to confirmatory analyses of the longitudinal data using structural equation modeling (SEM). The SEM will include confirmatory factor analysis to test the clarity of our conceptual categories and independence of our outcome measures, longitudinal change modeling to test the direct effects of time 1 predictors on time 2 outcomes, multiple groups modeling to evaluate hypotheses from our bi-dimensional model, and incomplete data modeling to identify and compensate for selective attrition. Results of the study will enhance our understanding of the natural course of health decline and development of secondary conditions, lead to refined predictive models, and will serve as a basis for developing prevention strategies to limit and/or prevent these conditions among people with SCI.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS048117-04
Application #
7535015
Study Section
Special Emphasis Panel (ZRG1-HOP-C (90))
Program Officer
Kleitman, Naomi
Project Start
2006-01-01
Project End
2010-12-31
Budget Start
2009-01-01
Budget End
2009-12-31
Support Year
4
Fiscal Year
2009
Total Cost
$457,652
Indirect Cost
Name
Medical University of South Carolina
Department
Other Health Professions
Type
Schools of Allied Health Profes
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Dismuke, C E; Egede, L E; Saunders, L et al. (2015) Diabetes increases financial burden of individuals with traumatic spinal cord injury (TSCI). Spinal Cord 53:135-8
Krause, J S; Dismuke, C E; Acuna, J et al. (2014) Race-ethnicity and poverty after spinal cord injury. Spinal Cord 52:133-8
Park, Sookyoung; Nozaki, Kenkichi; Smith, Joshua A et al. (2014) Cross-talk between IGF-1 and estrogen receptors attenuates intracellular changes in ventral spinal cord 4.1 motoneuron cells because of interferon-gamma exposure. J Neurochem 128:904-18
Saunders, Lee L; Krause, James S; DiPiro, Nicole D et al. (2013) Ambulation and complications related to assistive devices after spinal cord injury. J Spinal Cord Med 36:652-9
Krause, James S; Saunders, Lee L; Dipiro, Nicole D et al. (2013) Theoretical Risk and Prevention Model for Secondary Health Conditions and Mortality After SCI: 15 Years of Research. Top Spinal Cord Inj Rehabil 19:15-24
Park, Sookyoung; Nozaki, Kenkichi; Guyton, M Kelly et al. (2012) Calpain inhibition attenuated morphological and molecular changes in skeletal muscle of experimental allergic encephalomyelitis rats. J Neurosci Res 90:2134-45
Krause, J S; Saunders, L L (2012) Socioeconomic and behavioral risk factors for mortality: do risk factors observed after spinal cord injury parallel those from the general USA population? Spinal Cord 50:609-13
Krause, James S; Saunders, Lee L (2012) Do Risk Factors for Mortality after Spinal Cord Injury Parallel those from the General USA Population? Top Spinal Cord Inj Rehabil 18:113-117
Saunders, Lee L; Krause, James S; Acuna, Joshua (2012) Association of race, socioeconomic status, and health care access with pressure ulcers after spinal cord injury. Arch Phys Med Rehabil 93:972-7
Krause, J S; Saunders, L L; Zhai, Y (2012) Stability of predictors of mortality after spinal cord injury. Spinal Cord 50:281-4

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